Prostaglandinski D2 receptor

Из Википедије, слободне енциклопедије
Prostaglandinski D2 receptor (DP)
Identifikatori
Simboli PTGDR; AS1; ASRT1; DP; DP1; PTGDR1
Vanjski ID OMIM604687 MGI102966 HomoloGene736 IUPHAR: DP1 GeneCards: PTGDR Gene
Pregled RNK izražavanja
PBB GE PTGDR 215894 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 5729 19214
Ensembl ENSG00000168229 ENSMUSG00000071489
UniProt Q13258 P70263
RefSeq (mRNA) NM_000953.2 NM_008962.4
RefSeq (protein) NP_000944.1 NP_032988.3
Lokacija (UCSC) Chr 14:
52.73 - 52.74 Mb
Chr 14:
45.47 - 45.48 Mb
PubMed pretraga [1] [2]

Prostaglandinski D2 receptor (DP1) je G protein spregnuti receptor, kodiran PTGDR genom. Njegov endogeni ligand je prostaglandin D2.[1]

Mechanism[уреди]

DP1 je G protein spregnuti receptor. Njegova aktivnosti je uglavnom posredovana G-S proteinima koji stimulišu adenilat ciklazu, što dovodi do povišenja intracelularnog cAMP i Ca2+.

Funkcija[уреди]

Ispitivanja na nokaut miševima sugeriraju da ligand ovog receptora, prostaglandin D2 (PGD2), funkcioniše kao posrednik izveden iz mastocita koji podstiče astmatične response.[1] On uzrokuje vazodilataciju

Reference[уреди]

Literatura[уреди]

  • Boyce JA (2004). „The role of mast cells in asthma”. Prostaglandins Leukot. Essent. Fatty Acids. 69 (2–3): 195—205. doi:10.1016/S0952-3278(03)00081-4. PMID 12895603. 
  • Chiba T, Kanda A, Ueki S; et al. (2007). „Possible novel receptor for PGD2 on human bronchial epithelial cells”. Int. Arch. Allergy Immunol. 143 Suppl 1: 23—7. doi:10.1159/000101400. PMID 17541272. 
  • Senior J, Sangha R, Baxter GS; et al. (1992). „In vitro characterization of prostanoid FP-, DP-, IP- and TP-receptors on the non-pregnant human myometrium”. Br. J. Pharmacol. 107 (1): 215—21. PMC 1907618слободно за читање. PMID 1422574. 
  • Boie Y, Sawyer N, Slipetz DM; et al. (1995). „Molecular cloning and characterization of the human prostanoid DP receptor”. J. Biol. Chem. 270 (32): 18910—6. doi:10.1074/jbc.270.32.18910. PMID 7642548. 
  • Ishikawa TO, Tamai Y, Rochelle JM; et al. (1997). „Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors”. Genomics. 32 (2): 285—8. doi:10.1006/geno.1996.0118. PMID 8833158. 
  • Kobayashi T, Ushikubi F, Narumiya S (2000). „Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis”. J. Biol. Chem. 275 (32): 24294—303. doi:10.1074/jbc.M002437200. PMID 10827082. 
  • Wright DH, Ford-Hutchinson AW, Chadee K, Metters KM (2001). „The human prostanoid DP receptor stimulates mucin secretion in LS174T cells”. Br. J. Pharmacol. 131 (8): 1537—45. doi:10.1038/sj.bjp.0703688. PMC 1572485слободно за читање. PMID 11139429. 
  • Gervais FG, Cruz RP, Chateauneuf A; et al. (2002). „Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP”. J. Allergy Clin. Immunol. 108 (6): 982—8. doi:10.1067/mai.2001.119919. PMID 11742277. 
  • Noguchi E, Shibasaki M, Kamioka M; et al. (2002). „New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes”. Clin. Exp. Allergy. 32 (1): 93—6. doi:10.1046/j.0022-0477.2001.01261.x. PMID 12002745. 
  • Hakonarson H, Bjornsdottir US, Halapi E; et al. (2002). „A Major Susceptibility Gene for Asthma Maps to Chromosome 14q24”. Am. J. Hum. Genet. 71 (3): 483—91. doi:10.1086/342205. PMC 379187слободно за читање. PMID 12119603. 
  • Iwasaki M, Nagata K, Takano S; et al. (2002). „Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis”. J. Invest. Dermatol. 119 (3): 609—16. doi:10.1046/j.1523-1747.2002.01862.x. PMID 12230502. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. doi:10.1073/pnas.242603899. PMC 139241слободно за читање. PMID 12477932. 
  • Moreland RB, Nehra A, Kim NN; et al. (2003). „Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle”. Int. J. Impot. Res. 14 (6): 446—52. doi:10.1038/sj.ijir.3900900. PMID 12494276. 
  • Faveeuw C, Gosset P, Bureau F; et al. (2003). „Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways”. Eur. J. Immunol. 33 (4): 889—98. doi:10.1002/eji.200323330. PMID 12672054. 
  • Angeli V, Staumont D, Charbonnier AS; et al. (2004). „Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses”. J. Immunol. 172 (6): 3822—9. PMID 15004188. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. doi:10.1101/gr.2596504. PMC 528928слободно за читање. PMID 15489334. 
  • Oguma T, Palmer LJ, Birben E; et al. (2004). „Role of prostanoid DP receptor variants in susceptibility to asthma”. N. Engl. J. Med. 351 (17): 1752—63. doi:10.1056/NEJMoa031785. PMID 15496624. 
  • Spik I, Brénuchon C, Angéli V; et al. (2005). „Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse”. J. Immunol. 174 (6): 3703—8. PMID 15749909. 
  • Hirano Y, Shichijo M, Deguchi M; et al. (2007). „Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells”. Eur. J. Pharmacol. 560 (1): 81—8. doi:10.1016/j.ejphar.2007.01.003. PMID 17307163. 

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