5-HT2C receptor

Из Википедије, слободне енциклопедије
5-hidroksitriptaminski (serotoninski) receptor 2C
Identifikatori
Simboli HTR2C; 5-HT2C; 5-HTR2C; HTR1C
Vanjski ID OMIM312861 MGI96281 HomoloGene20242 GeneCards: HTR2C Gene
Pregled RNK izražavanja
PBB GE HTR2C 211479 s at tn.png
PBB GE HTR2C 207307 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3358 15560
Ensembl ENSG00000147246 ENSMUSG00000041380
UniProt P28335 Q8BUB1
RefSeq (mRNA) NM_000868.2 NM_008312.4
RefSeq (protein) NP_000859.1 NP_032338.3
Lokacija (UCSC) Chr X:
113.82 - 114.14 Mb
Chr X:
143.4 - 143.63 Mb
PubMed pretraga [1] [2]

5-HT2C receptor je tip 5-HT receptor koji vezuje endogeni neurotransmiter serotonin (5-hidroksitriptamin, 5-HT). On je G protein-spregnuti receptor (GPCR) koji deluje kro Gq/G11 i posreduje ekscitatornu neurotransmisiju. HTR2C isto tako označava humani gen koji kodira receptor,[1][2] koji je lociran na X hromozomu. Pošto muškarci imaju jednu kopiju ovog gena, a kod žena jedna od kopija je represivna, polimorfizmi ovog receptora mogu da imaju različiti uticaj u zavisnosti od pola.

Distribucija[уреди]

5-HT2C receptori su distribuirani širom perifernog humanog mozga.

Funkcija[уреди]

5-HT2C receptor je jedno od mnogih mesta vezivanja serotonina. Aktivacija ovog receptora serotoninom inhibira otpuštanje dopamina i norepinefrina u pojedinim oblastima mozga.[3]

5-HT2C receptori imaju znatan udeo u regulaciji raspoloženja, anksioznosti, ishrani, i reproduktivnom ponašanju.[4] 5-HT2C receptori regulišu dopaminsko otpuštanje u striatumu, prefrontalnom korteksu, nucleus accumbensu, hipokampusu, hipotalamusu, i amigdali, između ostalih.

Ligandi[уреди]

Interakcije[уреди]

Za 5-HT2C receptor je pokazano da interaguje sa MPDZ.[5][6]

Vidi još[уреди]

Literatura[уреди]

  1. „Entrez Gene: HTR2C 5-hydroxytryptamine (serotonin) receptor 2C”. 
  2. Stam NJ, Vanderheyden P, van Alebeek C, Klomp J, de Boer T, van Delft AM, Olijve W (1994). „Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor”. Eur. J. Pharmacol. 269 (3): 339—48. doi:10.1016/0922-4106(94)90042-6. PMID 7895773. 
  3. Alex KD, Yavanian GJ, McFarlane HG, Pluto CP, Pehek EA (2005). „Modulation of dopamine release by striatal 5-HT2C receptors”. Synapse. 55 (4): 242—51. doi:10.1002/syn.20109. PMID 15668911. 
  4. Heisler LK, Zhou L, Bajwa P, Hsu J, Tecott LH (2007). „Serotonin 5-HT2C receptors regulate anxiety-like behavior”. Genes, Brain and Behavior. 6 (5): 491—6. doi:10.1111/j.1601-183X.2007.00316.x. PMID 17451451. 
  5. Becamel, C; Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C (2001). „Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1”. J. Biol. Chem. United States. 276 (16): 12974—82. doi:10.1074/jbc.M008089200. ISSN 0021-9258. PMID 11150294. 
  6. Ullmer, C; Schmuck K, Figge A, Lübbert H (1998). „Cloning and characterization of MUPP1, a novel PDZ domain protein”. FEBS Lett. NETHERLANDS. 424 (1-2): 63—8. doi:10.1016/S0014-5793(98)00141-0. ISSN 0014-5793. PMID 9537516. 

Dodatna literatura[уреди]

  • Niswender CM, Sanders-Bush E, Emeson RB (1999). „Identification and characterization of RNA editing events within the 5-HT2C receptor.”. Ann. N. Y. Acad. Sci. 861 (1 ADVANCES IN S): 38—48. doi:10.1111/j.1749-6632.1998.tb10171.x. PMID 9928237. 
  • Hoyer D, Hannon JP, Martin GR (2002). „Molecular, pharmacological and functional diversity of 5-HT receptors.”. Pharmacol. Biochem. Behav. 71 (4): 533—54. doi:10.1016/S0091-3057(01)00746-8. PMID 11888546. 
  • Raymond JR, Mukhin YV, Gelasco A; et al. (2002). „Multiplicity of mechanisms of serotonin receptor signal transduction.”. Pharmacol. Ther. 92 (2-3): 179—212. doi:10.1016/S0163-7258(01)00169-3. PMID 11916537. 
  • Van Oekelen D, Luyten WH, Leysen JE (2003). „5-HT2A and 5-HT2C receptors and their atypical regulation properties.”. Life Sci. 72 (22): 2429—49. doi:10.1016/S0024-3205(03)00141-3. PMID 12650852. 
  • Reynolds GP, Templeman LA, Zhang ZJ (2005). „The role of 5-HT2C receptor polymorphisms in the pharmacogenetics of antipsychotic drug treatment.”. Prog. Neuropsychopharmacol. Biol. Psychiatry. 29 (6): 1021—8. doi:10.1016/j.pnpbp.2005.03.019. PMID 15953671. 
  • Millan MJ (2006). „Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies.”. Therapie. 60 (5): 441—60. doi:10.2515/therapie:2005065. PMID 16433010. 
  • Milatovich A, Hsieh CL, Bonaminio G; et al. (1993). „Serotonin receptor 1c gene assigned to X chromosome in human (band q24) and mouse (bands D-F4).”. Hum. Mol. Genet. 1 (9): 681—4. doi:10.1093/hmg/1.9.681. PMID 1302605. 
  • Saltzman AG, Morse B, Whitman MM; et al. (1992). „Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes.”. Biochem. Biophys. Res. Commun. 181 (3): 1469—78. doi:10.1016/0006-291X(91)92105-S. PMID 1722404. 
  • Lappalainen J, Zhang L, Dean M; et al. (1995). „Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C).”. Genomics. 27 (2): 274—9. doi:10.1006/geno.1995.1042. PMID 7557992. 
  • Tecott LH, Sun LM, Akana SF; et al. (1995). „Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors.”. Nature. 374 (6522): 542—6. doi:10.1038/374542a0. PMID 7700379. 
  • Stam NJ, Vanderheyden P, van Alebeek C; et al. (1995). „Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor.”. Eur. J. Pharmacol. 269 (3): 339—48. doi:10.1016/0922-4106(94)90042-6. PMID 7895773. 
  • Xie E, Zhu L, Zhao L, Chang LS (1996). „The human serotonin 5-HT2C receptor: complete cDNA, genomic structure, and alternatively spliced variant.”. Genomics. 35 (3): 551—61. doi:10.1006/geno.1996.0397. PMID 8812491. 
  • Burns CM, Chu H, Rueter SM; et al. (1997). „Regulation of serotonin-2C receptor G-protein coupling by RNA editing.”. Nature. 387 (6630): 303—8. doi:10.1038/387303a0. PMID 9153397. 
  • Brennan TJ, Seeley WW, Kilgard M; et al. (1997). „Sound-induced seizures in serotonin 5-HT2c receptor mutant mice.”. Nat. Genet. 16 (4): 387—90. doi:10.1038/ng0897-387. PMID 9241279. 
  • Ullmer C, Schmuck K, Figge A, Lübbert H (1998). „Cloning and characterization of MUPP1, a novel PDZ domain protein.”. FEBS Lett. 424 (1-2): 63—8. doi:10.1016/S0014-5793(98)00141-0. PMID 9537516. 
  • Samochowiec J, Smolka M, Winterer G; et al. (1999). „Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability.”. Am. J. Med. Genet. 88 (2): 126—30. doi:10.1002/(SICI)1096-8628(19990416)88:2<126::AID-AJMG6>3.0.CO;2-M. PMID 10206230. 
  • Cargill M, Altshuler D, Ireland J; et al. (1999). „Characterization of single-nucleotide polymorphisms in coding regions of human genes.”. Nat. Genet. 22 (3): 231—8. doi:10.1038/10290. PMID 10391209. 
  • Marshall SE, Bird TG, Hart K, Welsh KI (2000). „Unified approach to the analysis of genetic variation in serotonergic pathways.”. Am. J. Med. Genet. 88 (6): 621—7. doi:10.1002/(SICI)1096-8628(19991215)88:6<621::AID-AJMG9>3.0.CO;2-H. PMID 10581480. 
  • Backstrom JR, Price RD, Reasoner DT, Sanders-Bush E (2000). „Deletion of the serotonin 5-HT2C receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses.”. J. Biol. Chem. 275 (31): 23620—6. doi:10.1074/jbc.M000922200. PMID 10816555.