5-HT1F receptor

Из Википедије, слободне енциклопедије
5-hidroksitriptaminski (serotoninski) receptor 1F
Identifikatori
Simboli HTR1F; 5-HT1F; HTR1EL; MR77
Vanjski ID OMIM182134 MGI99842 HomoloGene37361 IUPHAR: 5-HT1F GeneCards: HTR1F Gene
Pregled RNK izražavanja
PBB GE HTR1F 221458 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3355 15557
Ensembl ENSG00000179097 ENSMUSG00000050783
UniProt P30939 Q543V2
RefSeq (mRNA) NM_000866 NM_008310
RefSeq (protein) NP_000857 NP_032336
Lokacija (UCSC) Chr 3:
88.12 - 88.12 Mb
Chr 16:
64.87 - 65.05 Mb
PubMed pretraga [1] [2]

5-HT1F receptor (5-hidroksitriptaminski (serotoninski) receptor 1F, HTR1F je 5-HT1 receptor. On je kodiran istoimenim humanim genom.[1][2][3][4][5]

Ligandi[уреди]

Agonisti[уреди]

  • 5-n-Butirilokis-DMT[6]: >60-puta je selektivniji u odnosu na 5-HT1E receptor
  • BRL-54443 - mešoviti 5-HT1E/1F agonist
  • Eletriptan - mešoviti 5-HT1B/1D/1E/1F/2B/7 agonist
  • LY-334,370[7] - kao i srodni benzamidi[8]
  • LY-344,864 (N-[(3R)-3-(Dimetilamino)-2,3,4,9-tetrahidro-1H-karbazol-6-il]-4-fluorobenzamid)
  • Naratriptan - mešoviti 5-HT1B/1D/1F agonist

Antagonisti[уреди]

Selektivni antagonisti 5HT1F receptora nisu dostupni.

Vidi još[уреди]

Literatura[уреди]

  1. „Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F”. 
  2. Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (1993). „Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase”. Proc. Natl. Acad. Sci. U.S.A. 90 (2): 408—12. PMC 45671Слободан приступ. PMID 8380639. doi:10.1073/pnas.90.2.408. 
  3. Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (1993). „Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes”. Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2184—8. PMC 46050Слободан приступ. PMID 8384716. doi:10.1073/pnas.90.6.2184. 
  4. Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). „Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)”. Mol. Membr. Biol. 14 (3): 133—5. PMID 9394293. doi:10.3109/09687689709048173. 
  5. Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (1998). „Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients”. Am. J. Med. Genet. 77 (5): 415—20. PMID 9632173. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. 
  6. PMID 21422162
  7. Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL (2005). „[3H]-LY-334,370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties”. Naunyn Schmiedebergs Arch. Pharmacol. 371 (3): 169—77. PMID 15900510. doi:10.1007/s00210-005-1035-9. 
  8. Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC (2004). „Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists”. Bioorg. Med. Chem. Lett. 14 (24): 6011—6. PMID 15546719. doi:10.1016/j.bmcl.2004.09.079. 

Dodatna literatura[уреди]

Spoljašnje veze[уреди]

  • „5-HT1F. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.