Melatoninski receptor 1A

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Melatoninski receptor 1A
Identifikatori
Simboli MTNR1A; MEL-1A-R; MT1
Vanjski ID OMIM600665 MGI102967 HomoloGene21207 IUPHAR: MT1 GeneCards: MTNR1A Gene
Pregled RNK izražavanja
PBB GE MTNR1A 221369 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 4543 17773
Ensembl ENSG00000168412 ENSMUSG00000054764
UniProt P48039 Q61184
RefSeq (mRNA) NM_005958.3 NM_008639.2
RefSeq (protein) NP_005949.1 NP_032665.1
Lokacija (UCSC) Chr 4:
187.35 - 187.48 Mb
Chr 8:
46.15 - 46.17 Mb
PubMed pretraga [1] [2]

Melatoninski receptor tip 1A je protein koji je kod ljudi kodiran MTNR1A genom.[1][2]

MT1 protein je jedan od dva receptora sa visokim afinitetom za melatonin, koji je primarni hormon epifize. Ovaj receptor je G protein spregnuti 7-transmembranski receptor koji je odgovoran za dejstvo melatonina na sisarski cirkadijanski ritam i reproduktivne promene na koje utiče dužina dana. Ovaj receptor je integralni membranski protein koji je lociran u dva specifična moždana regiona. Hipotalamusno suprahiazmatično jedro učestvuju u cirkadijanskom ritmu, dok je hipofizni pars tuberalis odgovoran za reproduktivne efekte melatonina.[2]

Vidi još[уреди]

Reference[уреди]

  1. ^ Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM (1995). „Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)”. Genomics. 27 (2): 355—7. PMID 7558006. doi:10.1006/geno.1995.1056. 
  2. 2,0 2,1 „Entrez Gene: MTNR1A melatonin receptor 1A”. 

Literatura[уреди]

  • Brzezinski A; Brzezinski, Amnon (1997). „Melatonin in humans”. N. Engl. J. Med. 336 (3): 186—95. PMID 8988899. doi:10.1056/NEJM199701163360306. 
  • Khan AU, Olson DL (1975). „Physical therapy and exercise-induced bronchospasm”. Physical therapy. 55 (8): 878—81. PMID 1144527. 
  • Reppert SM, Weaver DR, Ebisawa T (1994). „Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses”. Neuron. 13 (5): 1177—85. PMID 7946354. doi:10.1016/0896-6273(94)90055-8. 
  • Witt-Enderby PA, Dubocovich ML (1996). „Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells”. Mol. Pharmacol. 50 (1): 166—74. PMID 8700109. 
  • Witt-Enderby PA, Masana MI, Dubocovich ML (1998). „Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor”. Endocrinology. 139 (7): 3064—71. PMID 9645677. doi:10.1210/en.139.7.3064. 
  • Ebisawa T; Kajimura N; Uchiyama M; et al. (1999). „Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders”. Biochem. Biophys. Res. Commun. 262 (3): 832—7. PMID 10471411. doi:10.1006/bbrc.1999.1308. 
  • Brydon L; Roka F; Petit L; et al. (2000). „Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins”. Mol. Endocrinol. 13 (12): 2025—38. PMID 10598579. doi:10.1210/me.13.12.2025. 
  • Niles LP; Wang J; Shen L; et al. (2000). „Melatonin receptor mRNA expression in human granulosa cells”. Mol. Cell. Endocrinol. 156 (1–2): 107—10. PMID 10612428. doi:10.1016/S0303-7207(99)00135-5. 
  • Song CK, Bartness TJ (2001). „CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity”. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 (2): R666—72. PMID 11448873. 
  • Roy D; Angelini NL; Fujieda H; et al. (2001). „Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin”. Endocrinology. 142 (11): 4711—20. PMID 11606436. doi:10.1210/en.142.11.4711. 
  • Savaskan E; Olivieri G; Meier F; et al. (2002). „Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients”. J. Pineal Res. 32 (1): 59—62. PMID 11841602. doi:10.1034/j.1600-079x.2002.00841.x. 
  • Savaskan E; Wirz-Justice A; Olivieri G; et al. (2002). „Distribution of melatonin MT1 receptor immunoreactivity in human retina”. J. Histochem. Cytochem. 50 (4): 519—26. PMID 11897804. 
  • Ayoub MA; Couturier C; Lucas-Meunier E; et al. (2002). „Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer”. J. Biol. Chem. 277 (24): 21522—8. PMID 11940583. doi:10.1074/jbc.M200729200. 
  • Yuan L; Collins AR; Dai J; et al. (2003). „MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells”. Mol. Cell. Endocrinol. 192 (1–2): 147—56. PMID 12088876. doi:10.1016/S0303-7207(02)00029-1. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Slominski A; Pisarchik A; Zbytek B; et al. (2003). „Functional activity of serotoninergic and melatoninergic systems expressed in the skin”. J. Cell. Physiol. 196 (1): 144—53. PMID 12767050. doi:10.1002/jcp.10287. 
  • Morcuende JA; Minhas R; Dolan L; et al. (2004). „Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis”. Spine. 28 (17): 2025—8; discussion 2029. PMID 12973153. doi:10.1097/01.BRS.0000083235.74593.49. 
  • Aust S; Thalhammer T; Humpeler S; et al. (2004). „The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia”. J. Pineal Res. 36 (1): 43—8. PMID 14675129. doi:10.1046/j.1600-079X.2003.00095.x. 

Spoljašnje veze[уреди]