Metabotropni glutamatni receptor 7

Metabotropni glutamatni receptor 7
Metabotropni glutamatni receptor 7
	PDB prikaz baziran na 2e4z.
Dostupne strukture
	3MQ4
Identifikatori
Simboli	GRM7; GLUR7; GPRC1G; MGLU7; MGLUR7
Vanjski ID	OMIM: 604101 MGI: 1351344 HomoloGene: 20233 IUPHAR: mGlu7 GeneCards: GRM7 Gene
Ontologija gena
Molekularna funkcija	• aktivnost grupe III metabotropnih glutamatnih receptora; • aktivnost prenosa signala; • receptorska aktivnost; • aktivnost G protein spregnutog receptora; • aktivnost naponom kontrolisanog kalcijumovog kanala; • aktivnost regulatora kalcijumovog kanala; • vezivanje jona kalcijuma; • aktivnost glutamatnog receptora; • aktivnsot inhibitor adenylat ciklaze; • glutamatno vezivanje; • vezivanje PDZ domena; • serinsko vezivanje;
Celularna komponenta	• ćelijska membrana; • integralno sa ćelijskom membranom; • ćelijski korteks; • integralno sa membranom; • akson; • dendrit; • asimetrična sinapsa; • presinaptička membrana; • dendritna osovina; • postsinaptička membrana; • presinaptička aktivna zona;
Biološki proces	• uslovna averzija ukusa; • respons na strah; • negativna regulacija aktivnosti adenilat ciklaze; • sinaptička transmisija; • senzorna percepcija zvuka; • senzorna percepcija mirisa; • kratkotrajna memorija; • negativna regulacija glutamatne sekrecije; • ponašanje odraslih; • negativna regulacija cAMP biosinthetčkog procesa;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	2917
Ensembl	ENSG00000196277
UniProt	Q14831
RefSeq (mRNA)	NM_000844.3
RefSeq (protein)	NP_000835.1
Lokacija (UCSC)	Chr 3:; 6.81 - 7.78 Mb
PubMed pretraga	[1]

Metabotropni glutamatni receptor 7 je protein koji je kod ljudi kodiran GRM7 genom.^[1]^[2]^[3]

Funkcija

L-glutamat je jedan od glavnih ekscitatornih neurotransmitera u centralnom nervnom sistemu. On aktivira jonotropne i metabotropne glutamatne receptore. Glutamatergična neurotransmisija učestvuje u većini aspekata normalih moždanih funkcija i njena perturbacija se javlja kod mnogih neuropatoloških oboljenja. Metabotropni glutamatni receptori su familija G protein spregnutih receptora, koja se deli u tri grupe na osnovu homologije sekvenci, mehanizama prenosa signala, i farmakoloških svojstava. Grupa I obuhvata GRM1 i GRM5. Ti receptori aktiviraju fosfolipazu C. Grupa II obuhvata GRM2 i GRM3, dok grupa III obuhvata GRM4, GRM6, GRM7 i GRM8. Receptori grupe II i III su povezani inhibicijom kaskade cikličnog AMP-a ali se razlikuju u njihovim selektivnostima za agoniste.^[3]

Ligandi

Agonisti

AMN082: alosterni agonist;^[4]^[5] indukuje brzu internalizaciju;^[6] non-glutamatergic binding component^[5]

Antagonisti

MMPIP: alosterni antagonist/inverzni agonist^[7]

Interakcije

Metabotropni glutamatni receptor 7 formira interakcije sa PICK1.^[8]

Reference

^ Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi S (1994). „Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction”. J Biol Chem. 269 (2): 1231—6. PMID 8288585.
^ Makoff A, Pilling C, Harrington K, Emson P (1997). „Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS”. Brain Res Mol Brain Res. 40 (1): 165—70. PMID 8840028. doi:10.1016/0169-328X(96)00110-6.
^ ^а ^б „Entrez Gene: GRM7 glutamate receptor, metabotropic 7”.
^ Li X, Gardner EL, Xi ZX (2008). „The Metabotropic Glutamate Receptor 7 (mGluR7) Allosteric Agonist AMN082 Modulates Nucleus Accumbens GABA and Glutamate, but not Dopamine, in Rats”. Neuropharmacology. 54 (3): 542—51. PMC 2410088 . PMID 18155073. doi:10.1016/j.neuropharm.2007.11.005.
^ ^а ^б Palucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A (2007). „Activation of the mGlu7 receptor elicits antidepressant-like effects in mice”. Psychopharmacology (Berl.). 194 (4): 555—62. PMID 17622518. doi:10.1007/s00213-007-0856-2.
^ Pelkey KA, Yuan X, Lavezzari G, Roche KW, McBain CJ (2007). „mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082”. Neuropharmacology. 52 (1): 108—17. PMID 16914173. doi:10.1016/j.neuropharm.2006.07.020.
^ Suzuki G; Tsukamoto N; Fushiki H; et al. (2007). „In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists”. J. Pharmacol. Exp. Ther. 323 (1): 147—56. PMID 17609420. doi:10.1124/jpet.107.124701.
^ Dev, K K; et al. (2000). „PICK1 interacts with and regulates PKC phosphorylation of mGLUR7”. J. Neurosci. UNITED STATES. 20 (19): 7252—7. PMID 11007882.

Literatura

Scherer SW; Duvoisin RM; Kuhn R; et al. (1997). „Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q”. Genomics. 31 (2): 230—3. PMID 8824806. doi:10.1006/geno.1996.0036.
Flor PJ; Van Der Putten H; Rüegg D; et al. (1997). „A novel splice variant of a metabotropic glutamate receptor, human mGluR7b”. Neuropharmacology. 36 (2): 153—9. PMID 9144652. doi:10.1016/S0028-3908(96)00176-1.
Wu S; Wright RA; Rockey PK; et al. (1998). „Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells”. Brain Res. Mol. Brain Res. 53 (1–2): 88—97. PMID 9473604. doi:10.1016/S0169-328X(97)00277-5.
Nakajima Y, Yamamoto T, Nakayama T, Nakanishi S (1999). „A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7”. J. Biol. Chem. 274 (39): 27573—7. PMID 10488094. doi:10.1074/jbc.274.39.27573.
O'Connor V; El Far O; Bofill-Cardona E; et al. (1999). „Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling”. Science. 286 (5442): 1180—4. PMID 10550060. doi:10.1126/science.286.5442.1180.
Barbon A, Ferraboli S, Barlati S (2000). „Assignment of the human metabotropic glutamate receptor gene GRM7 to chromosome 3p26.1→p25.2 by radiation hybrid mapping”. Cytogenet. Cell Genet. 88 (3–4): 288. PMID 10828612. doi:10.1159/000015541.
Dev KK; Nakajima Y; Kitano J; et al. (2001). „PICK1 interacts with and regulates PKC phosphorylation of mGLUR7”. J. Neurosci. 20 (19): 7252—7. PMID 11007882.
Bolonna AA; Kerwin RW; Munro J; et al. (2001). „Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia”. Schizophr. Res. 47 (1): 99—103. PMID 11163549. doi:10.1016/S0920-9964(99)00235-2.
Hirbec H; Perestenko O; Nishimune A; et al. (2002). „The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs”. J. Biol. Chem. 277 (18): 15221—4. PMID 11891216. doi:10.1074/jbc.C200112200.
Enz R (2002). „The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7”. FEBS Lett. 514 (2–3): 184—8. PMID 11943148. doi:10.1016/S0014-5793(02)02361-X.
Saugstad JA; Yang S; Pohl J; et al. (2002). „Interaction between metabotropic glutamate receptor 7 and alpha tubulin”. J. Neurochem. 80 (6): 980—8. PMC 2925652 . PMID 11953448. doi:10.1046/j.0022-3042.2002.00778.x.
Schulz HL, Stohr H, Weber BH (2002). „Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 (GRM7)”. Neurosci. Lett. 326 (1): 37—40. PMID 12052533. doi:10.1016/S0304-3940(02)00306-3.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
Kobayashi Y; Akiyoshi J; Kanehisa M; et al. (2007). „Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder”. Psychiatr. Genet. 17 (1): 9. PMID 17167337. doi:10.1097/YPG.0b013e32801118bc.

Spoljašnje veze

„Metabotropic Glutamate Receptors: mGlu₇”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.

[pmid8288585-1] Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi S (1994). „Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction”. J Biol Chem. 269 (2): 1231—6. PMID 8288585.

[pmid8840028-2] Makoff A, Pilling C, Harrington K, Emson P (1997). „Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS”. Brain Res Mol Brain Res. 40 (1): 165—70. PMID 8840028. doi:10.1016/0169-328X(96)00110-6.

[entrez-3] а ^б „Entrez Gene: GRM7 glutamate receptor, metabotropic 7”.

[4] Li X, Gardner EL, Xi ZX (2008). „The Metabotropic Glutamate Receptor 7 (mGluR7) Allosteric Agonist AMN082 Modulates Nucleus Accumbens GABA and Glutamate, but not Dopamine, in Rats”. Neuropharmacology. 54 (3): 542—51. PMC 2410088 . PMID 18155073. doi:10.1016/j.neuropharm.2007.11.005.

[pmid17622518-5] а ^б Palucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A (2007). „Activation of the mGlu7 receptor elicits antidepressant-like effects in mice”. Psychopharmacology (Berl.). 194 (4): 555—62. PMID 17622518. doi:10.1007/s00213-007-0856-2.

[6] Pelkey KA, Yuan X, Lavezzari G, Roche KW, McBain CJ (2007). „mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082”. Neuropharmacology. 52 (1): 108—17. PMID 16914173. doi:10.1016/j.neuropharm.2006.07.020.

[7] Suzuki G; Tsukamoto N; Fushiki H; et al. (2007). „In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists”. J. Pharmacol. Exp. Ther. 323 (1): 147—56. PMID 17609420. doi:10.1124/jpet.107.124701.

[pmid11007882-8] Dev, K K; et al. (2000). „PICK1 interacts with and regulates PKC phosphorylation of mGLUR7”. J. Neurosci. UNITED STATES. 20 (19): 7252—7. PMID 11007882.

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