P2RY11
| Purinski receptor P2Y, G-protein spregnuti, 11 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | P2RY11; P2Y11 | ||||||||||
| Vanjski ID | OMIM: 602697 IUPHAR: P2Y11 GeneCards: P2RY11 Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5032 | n/a | |||||||||
| Ensembl | ENSG00000176130 | n/a | |||||||||
| UniProt | Q96G91 | n/a | |||||||||
| RefSeq (mRNA) | NM_002566 | n/a | |||||||||
| RefSeq (protein) | NP_002557 | n/a | |||||||||
| Lokacija (UCSC) |
Chr 19: 10.08 - 10.09 Mb | n/a | |||||||||
| PubMed pretraga | [1] | n/a | |||||||||
P2RY11 (P2Y purinoceptor 11) je protein je protein koji je kod ljudi kodiran P2RY11 genom.[1][2]
Protein kodiran ovim genom pripada familiji G-protein spregnutih receptora, koji su preferentno aktivirani nukleotidima adenozina i uridina. Ovaj receptor je spregnut sa stimulacijom puteva fosfoinozitida i adenilil ciklaze i ponaša se kao selektivni purinoceptor. Postoje prirodni združeni transkripti, koji nastaju intergenskim splajsovanjem ovog gena i neposredno prethodećeg gena (PPAN, koji kodira petar pan homolog). PPAN-P2RY11 iRNK je široko izražena i kodira fuzioni protein koji ima zajednički identitet individualnih genskih proizvoda.[2]
Vidi još[uredi | uredi izvor]
Literatura[uredi | uredi izvor]
- ^ Communi D, Govaerts C, Parmentier M, Boeynaems JM (1998). „Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase”. J Biol Chem. 272 (51): 31969—73. PMID 9405388. doi:10.1074/jbc.272.51.31969.
- ^ а б „Entrez Gene: P2RY11 purinergic receptor P2Y, G-protein coupled, 11”.
Dodatna literatura[uredi | uredi izvor]
- van der Weyden L, Conigrave AD, Morris MB (2000). „Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor.”. Immunol. Cell Biol. 78 (4): 369—74. PMID 10947861. doi:10.1046/j.1440-1711.2000.00918.x.
- Adams MD; Kerlavage AR; Fleischmann RD; et al. (1995). „Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.” (PDF). Nature. 377 (6547 Suppl): 3—174. PMID 7566098.
- Communi D; Suarez-Huerta N; Dussossoy D; et al. (2001). „Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes.”. J. Biol. Chem. 276 (19): 16561—6. PMID 11278528. doi:10.1074/jbc.M009609200.
- Moore DJ; Chambers JK; Wahlin JP; et al. (2001). „Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.”. Biochim. Biophys. Acta. 1521 (1-3): 107—19. PMID 11690642.
- Duhant X; Schandené L; Bruyns C; et al. (2002). „Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes.”. J. Immunol. 169 (1): 15—21. PMID 12077223.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Moreschi I; Bruzzone S; Nicholas RA; et al. (2006). „Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes.”. J. Biol. Chem. 281 (42): 31419—29. PMID 16926152. doi:10.1074/jbc.M606625200.
- Zylberg J, Ecke D, Fischer B, Reiser G (2007). „Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis.”. Biochem. J. 405 (2): 277—86. PMC 1904521 . PMID 17338680. doi:10.1042/BJ20061728.
Spoljašnje veze[uredi | uredi izvor]
- „P2Y Receptors: P2Y11”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.