Fluorolintan
 | |
| IUPAC ime | |
|---|---|
1-(1-(2-Fluorofenil)-2-feniletil)pirolidin | |
| Pravni status | |
| Pravni status |
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| Identifikatori | |
| PubChem | CID 137332216 |
| ChemSpider | 58838621 |
| UNII | S8L5P832B3  |
| Hemijski podaci | |
| Formula | C18H20FN |
| Molarna masa | 269,36 g·mol−1 |
| |
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Fluorolintan (takođe poznat kao 2-FPPP i 2-F-DPPy) je disocijativni anestetik koji se prodaje na internetu kao dizajnirana droga.[1][2][3][4]
Fluorolintan i srodni diariletilamini su antagonisti NMDA receptora[5] i proučavani su in vitro kao potencijalni tretmani za neurotoksične povrede,[6] depresiju[7] i kao simpatomimetici.[8]
Reference[уреди | уреди извор]
- ^ Wallach J, Kavanagh PV, McLaughlin G, Morris N, Power JD, Elliott SP, et al. (мај 2015). „Preparation and characterization of the 'research chemical' diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers”. Drug Testing and Analysis. 7 (5): 358—367. PMID 25044512. doi:10.1002/dta.1689.
- ^ „Analytical Report - Fluorolintane” (PDF). Nacionalni forenzični laboratorij (NFL). јануар 2016.
- ^ Wallach J, Colestock T, Agramunt J, Claydon MD, Dybek M, Filemban N, et al. (август 2019). „Pharmacological characterizations of the 'legal high' fluorolintane and isomers”. European Journal of Pharmacology. 857: 172427. PMC 6899220
. PMID 31152702. doi:10.1016/j.ejphar.2019.172427.
- ^ Dybek M, Wallach J, Kavanagh PV, Colestock T, Filemban N, Dowling G, et al. (август 2019). „Syntheses and analytical characterizations of the research chemical 1-[1-(2-fluorophenyl)-2-phenylethyl]pyrrolidine (fluorolintane) and five of its isomers”. Drug Testing and Analysis. 11 (8): 1144—1161. PMID 31033229. S2CID 139103681. doi:10.1002/dta.2608.
- ^ Berger ML, Schweifer A, Rebernik P, Hammerschmidt F (мај 2009). „NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds”. Bioorganic & Medicinal Chemistry. 17 (9): 3456—62. PMID 19345586. doi:10.1016/j.bmc.2009.03.025.
- ^ Gray NM, Cheng BK (1994). „Patent EP 0346791 B1 - 1,2-diarylethylamines for treatment of neurotoxic injury”.
- ^ Aspergren BD, Heinzelman RV (1963). „Patent US 3083139 A - Therapeutic 1-(1, 2-diphenylethyl) pyrrolidine for the management of depression”.
- ^ Heinzelman RV, Aspergren BD (јул 1953). „Compounds Containing the Pyrrolidine Ring. Analogs of Sympathomimetic Amines”. Journal of the American Chemical Society. 75 (14): 3409—3413. doi:10.1021/ja01110a033.
