Propilnorapomorfin

Из Википедије, слободне енциклопедије
Propilnorapomorfin
Propylnorapomorphine.svg
IUPAC ime
(6aS)-6-propil-5,6,6a,7-tetrahidro-4H-dibenzo[de,g]hinolin-10,11-diol
Klinički podaci
Način primene Oralno
Pravni status
Pravni status
  • Uncontrolled
Identifikatori
CAS broj 57559-68-9 ДаY
ATC kod none
PubChem CID 5311191
ChemSpider 4470712
Hemijski podaci
Formula C19H21NO2
Molarna masa 295,38 g/mol

N-n-Propilnorapomorfin (NPA) je derivat aporfina koji deluje kao dopaminski agonist. On je blisko srodan sa apomorfinom.[1][2] Pokazano je da kod glodara između ostalog proizvodi hiperaktivnost, stereotipiju, hipotermiju, antinocepciju, i erekciju.[3][4][5][6]

Reference[уреди]

  1. Miller RJ, Kelly PH, Neumeyer JL (1976). „Aporphines. 15. Action of aporphine alkaloids on dopaminergic mechanisms in rat brain”. European Journal of Pharmacology. 35 (1): 77—83. doi:10.1016/0014-2999(76)90302-2. PMID 943290. 
  2. Creese I, Padgett L, Fazzini E, Lopez F (1979). „3H-N-n-propylnorapomorphine: a novel agonist ligand for central dopamine receptors”. European Journal of Pharmacology. 56 (4): 411—2. doi:10.1016/0014-2999(79)90274-7. PMID 477735. 
  3. Menon MK, Clark WG, Neumeyer JL (1978). „Comparison of the dopaminergic effects of apomorphine and (-)-N-n-propylnorapomorphine”. European Journal of Pharmacology. 52 (1): 1—9. doi:10.1016/0014-2999(78)90015-8. PMID 569056. 
  4. Riffee WH, Wilcox RE, Smith RV (1979). „Stereotypic and hypothermic effects of apomorphine and N-n-propylnorapomorphine in mice”. European Journal of Pharmacology. 54 (3): 273—7. doi:10.1016/0014-2999(79)90086-4. PMID 570924. 
  5. Neumeyer JL; Reinhard JF; Dafeldecker WP; et al. (1976). „Aporphines. 14 Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10-hydroxyaporphines and 10-hydroxy-N-n-propylnoraporphine”. Journal of Medicinal Chemistry. 19 (1): 25—9. doi:10.1021/jm00223a006. PMID 942751. 
  6. Benassi-Benelli A, Ferrari F, Quarantotti BP (1979). „Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats”. Archives Internationales De Pharmacodynamie Et De Thérapie. 242 (2): 241—7. PMID 44457. 

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