RDS-127

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RDS-127
RDS-127 structure.png
IUPAC ime
4,7-dimetoksi-N,N-dipropil-2,3-dihidro-1H-inden-2-amin
Identifikatori
CAS broj 82668-32-4 ДаY
ATC kod none
PubChem CID 134064
Hemijski podaci
Formula C17H27NO2
Molarna masa 277,402 g/mol
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RDS-127 je lek koji se koristi u naučnim istraživanjima. On deluje kao agonist D2 sličnih receptora,[1] a manifestuje i serotoninske i adrenergičke efekte,[2][3][4][5] kao i antiholinergičko dejstvo.[6][7] U životinjskim studijama on pokazuje anoreksično dejstvo i stimuliše seksualni nagon.[8][9]

Reference[уреди]

  1. Arnerić SP, Long JP, Williams M; et al. (1983). „RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane): central effects of a new dopamine receptor agonist”. The Journal of Pharmacology and Experimental Therapeutics 224 (1): 161—70. PMID 6401334. 
  2. Arnerić SP, Roetker A, Long JP, Mott J, Barfknecht CF (1982). „Effects of semirigid methoxamine analogs on vascular smooth muscle: studies of methoxy-2-aminotetralin and 2-aminoindane derivatives”. Archives Internationales De Pharmacodynamie et De Thérapie 257 (2): 263—73. PMID 7114973. 
  3. Arnerić SP, Long JP (1984). „Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7-dimethoxyindane] has some centrally mediated cardiovascular actions”. The Journal of Pharmacy and Pharmacology 36 (5): 318—21. PMID 6145768. 
  4. Clark JT, Smith ER (1986). „Failure of pimozide and metergoline to antagonize the RDS-127-induced facilitation of ejaculatory behavior”. Physiology & Behavior 37 (1): 47—52. doi:10.1016/0031-9384(86)90382-3. PMID 3737722. 
  5. Rezaki YE, Ilhan M (1991). „Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae”. Archives Internationales De Pharmacodynamie et De Thérapie 310: 76—86. PMID 1685313. 
  6. Sahin I, Ilhan M (1988). „The antimuscarinic activity of a dopamine receptor agonist (RDS-127) differentiates M2-muscarinic receptors of heart, ileum and trachea in guinea-pig”. Archives Internationales De Pharmacodynamie et De Thérapie 296: 163—72. PMID 2907277. 
  7. Sahin I, Tuncer M, Ilhan M (1990). „Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice”. Archives Internationales De Physiologie et De Biochimie 98 (1): 7—9. doi:10.3109/13813459009115730. PMID 1692697. 
  8. Arnerić SP, Roetker A, Long JP (1982). „Potent anorexic-like effects of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in the rat: a comparison with other dopamine-receptor agonists”. Neuropharmacology 21 (9): 885—90. doi:10.1016/0028-3908(82)90080-6. PMID 6897285. 
  9. Kwong LL, Smith ER, Davidson JM, Peroutka SJ (1986). „Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and alpha 2-adrenergic receptors”. Behavioral Neuroscience 100 (5): 664—8. doi:10.1037/0735-7044.100.5.664. PMID 2877677. 

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