BTS 74,398

С Википедије, слободне енциклопедије
BTS 74,398
IUPAC ime
1-([1-(3,4-dihlorofenil)ciklobutil]-2-(3-diamintilaminopropiltio)etanon
Klinički podaci
Drugs.com74,398.html Monografija
Identifikatori
CAS broj548491-50-5 ДаY
ATC kodNone
PubChemCID 24838024
ChemSpider26325181 ДаY
UNIII3W0WCC63A ДаY
Hemijski podaci
FormulaC19H29Cl2N3OS
Molarna masa418,424
  • NCCN(CCN)CCCSCC(=O)C1(CCC1)c2ccc(Cl)c(Cl)c2
  • InChI=1S/C19H29Cl2N3OS/c20-16-4-3-15(13-17(16)21)19(5-1-6-19)18(25)14-26-12-2-9-24(10-7-22)11-8-23/h3-4,13H,1-2,5-12,14,22-23H2 ДаY
  • Key:OLQJWCYRPYGTJI-UHFFFAOYSA-N ДаY

BTS 74,398 je stimulativni lek sa centralnim dejstvom koji je razvijen za lečenje Parkinsonove bolesti. On inhibira sinaptičko ponovno uzimanje dopamina, serotonina i noradrenalina, što ga čini trostrukim inhibitorom ponovnog uzimanja.[1] Bio je efikasan na životinjskim modelima Parkinsonove bolesti,[2][3] ali je bio neuspešan u ispitivanjima na ljudima.[4]

Osobine[уреди | уреди извор]

BTS 74,398 je organsko jedinjenje, koje sadrži 19 atoma ugljenika i ima molekulsku masu od 418,424 Da.

Osobina Vrednost
Broj akceptora vodonika 5
Broj donora vodonika 2
Broj rotacionih veza 12
Particioni koeficijent[5] (ALogP) 2,9
Rastvorljivost[6] (logS, log(mol/L)) -6,4
Polarna površina[7] (PSA, Å2) 97,7

Reference[уреди | уреди извор]

  1. ^ Lane EL, Cheetham S, Jenner P (март 2005). „Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxytryptamine and noradrenaline receptors”. The Journal of Pharmacology and Experimental Therapeutics. 312 (3): 1124—31. PMID 15542624. S2CID 8208352. doi:10.1124/jpet.104.076554. 
  2. ^ Hansard MJ, Smith LA, Jackson MJ, Cheetham SC, Jenner P (јануар 2004). „The monoamine reuptake inhibitor BTS 74 398 fails to evoke established dyskinesia but does not synergise with levodopa in MPTP-treated primates”. Movement Disorders. 19 (1): 15—21. PMID 14743355. S2CID 26120965. doi:10.1002/mds.10596. 
  3. ^ Lane EL, Cheetham SC, Jenner P (јануар 2005). „Repeated administration of the monoamine reuptake inhibitor BTS 74 398 induces ipsilateral circling in the 6-hydroxydopamine lesioned rat without sensitizing motor behaviours”. The European Journal of Neuroscience. 21 (1): 179—86. PMID 15654855. S2CID 22417785. doi:10.1111/j.1460-9568.2004.03834.x. 
  4. ^ Lane EL, Cheetham S, Jenner P (2008). „Striatal output markers do not alter in response to circling behaviour in 6-OHDA lesioned rats produced by acute or chronic administration of the monoamine uptake inhibitor BTS 74 398”. Journal of Neural Transmission. 115 (3): 423—9. PMID 18250952. S2CID 195993. doi:10.1007/s00702-007-0854-x. 
  5. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  6. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  7. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura[уреди | уреди извор]

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