BP-897

Из Википедије, слободне енциклопедије
BP-897
BP-897 structure.png
IUPAC ime
N-[4-[4-(2-metoksifenil)piperazin-1-il]butil]naftalen-2-karboksamid
Identifikatori
CAS broj 314776-92-6 ДаY
ATC kod none
PubChem CID 3038495
ChEMBL CHEMBL25236 ДаY
Hemijski podaci
Formula C26H31N3O2
Molarna masa 417,542 g/mol
  (verify)

BP-897 je lek koji se koristi u naučnim istraživanjima. On deluje kao umereno selektivni parcijalni agonist dopaminski D3 receptora.[1] On je uglavnom korišćen za studiranje tretmana za kokainsku adikciju.[2][3][4][5][6][7][8]

Reference[уреди]

  1. Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, Schwartz JC, Everitt BJ, Sokoloff P (1999). „Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist”. Nature 400 (6742): 371—5. doi:10.1038/22560. PMID 10432116. 
  2. Beardsley PM, Sokoloff P, Balster RL, Schwartz JC (2001). „The D3R partial agonist, BP 897, attenuates the discriminative stimulus effects of cocaine and D-amphetamine and is not self-administered”. Behavioural Pharmacology 12 (1): 1—11. PMID 11270507. 
  3. Garcia-Ladona FJ, Cox BF (2003). „BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction”. CNS Drug Reviews 9 (2): 141—58. PMID 12847556. 
  4. Duarte C, Lefebvre C, Chaperon F, Hamon M, Thiébot MH (2003). „Effects of a dopamine D3 receptor ligand, BP 897, on acquisition and expression of food-, morphine-, and cocaine-induced conditioned place preference, and food-seeking behavior in rats”. Neuropsychopharmacology 28 (11): 1903—15. doi:10.1038/sj.npp.1300276. PMID 12915863. 
  5. Hsu A, Togasaki DM, Bezard E, Sokoloff P, Langston JW, Di Monte DA, Quik M (2004). „Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys”. The Journal of Pharmacology and Experimental Therapeutics 311 (2): 770—7. doi:10.1124/jpet.104.071142. PMID 15226382. 
  6. Gilbert JG, Newman AH, Gardner EL, Ashby CR, Heidbreder CA, Pak AC, Peng XQ, Xi ZX (2005). „Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors”. Synapse (New York, N.Y.) 57 (1): 17—28. doi:10.1002/syn.20152. PMID 15858839. 
  7. Spiller K, Xi ZX, Peng XQ, Newman AH, Ashby CR, Heidbreder C, Gaál J, Gardner EL (2008). „The selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in rats”. Psychopharmacology 196 (4): 533—42. doi:10.1007/s00213-007-0986-6. PMID 17985117. 
  8. Hocke C, Prante O, Salama I, Hübner H, Löber S, Kuwert T, Gmeiner P (2008). „18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor”. Chemmedchem 3 (5): 788—93. doi:10.1002/cmdc.200700327. PMID 18306190. 

Spoljašnje veze[уреди]