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LY-344,545

С Википедије, слободне енциклопедије
LY-344,545
Identifikatori
ATC kodnone
Hemijski podaci
FormulaC20H19NO5
Molarna masa353,37 g/mol

LY-344,545 je lek koji se koristi u naučnim istraživanjima. On deluje kao antagonist metabotropnog glutamatnog receptora mGluR5. On je epimer mGluR2/3-selektivnog antagonista LY-341,495.[1][2]

  1. ^ Ornstein PL, Bleisch TJ, Arnold MB, Kennedy JH, Wright RA, Johnson BG, Tizzano JP, Helton DR, Kallman MJ, Schoepp DD, Hérin M. 2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability. Journal of Medicinal Chemistry. 1998 Jan 29;41(3):358-78. PMID 9464367
  2. ^ Doherty AJ, Palmer MJ, Bortolotto ZA, Hargreaves A, Kingston AE, Ornstein PL, Schoepp DD, Lodge D, Collingridge GL. A novel, competitive mGlu(5) receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices. British Journal of Pharmacology. 2000 Sep;131(2):239-44. PMID 10991916

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