LY-293,284

Из Википедије, слободне енциклопедије
LY-293,284
LY293284 structure.png
IUPAC ime
(4R)-6-acetil-4-(di-n-propilamino)-1,3,4,5-tetrahidrobenz[c,d]indol
Identifikatori
CAS broj 141318-62-9 ДаY
ATC kod None
PubChem CID 132345
Hemijski podaci
Formula C19H26N2O
Molarna masa 298,423 g/mol
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LY-293,284 je istraživačka hemikalija. On deluje kao potentan i selektivan pun agonist 5-HT1A receptora. On je izveden putem nekoliko strukturnih simplifikacija na ergolinu baziranih halucinogena, LSD[1] On je selektivan za 5-HT1A sa preko 1000x selektivnošću u odnosu na druge tipove serotoninskog receptora i druge ciljeve.[2] On pokazuje anksiogene efekte u životinjskim studijama.[3]

Reference[уреди]

  1. Monte AP, Marona-Lewicka D, Lewis MM, Mailman RB, Wainscott DB, Nelson DL, Nichols DE (1998). „Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity”. Journal of Medicinal Chemistry. 41 (12): 2134—45. PMID 9622555. doi:10.1021/jm980076u. 
  2. Foreman MM, Fuller RW, Rasmussen K, Nelson DL, Calligaro DO, Zhang L, Barrett JE, Booher RN, Paget CJ, Flaugh ME (1994). „Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity”. The Journal of Pharmacology and Experimental Therapeutics. 270 (3): 1270—81. PMID 7523657. 
  3. Cao BJ, Rodgers RJ (1998). „Comparative effects of novel 5-HT1A receptor ligands, LY293284, LY315712 and LY297996, on plus-maze anxiety in mice”. Psychopharmacology. 139 (3): 185—94. PMID 9784072. doi:10.1007/s002130050703. 

Spoljašnje veze[уреди]