S-15,535

Из Википедије, слободне енциклопедије
(преусмерено са S-15535)
S-15,535
S-15535 structure.png
IUPAC ime
1-(2,3-dihidro-1,4-benzodioksin-8-il)-4-(2,3-dihidro-1H-inden-2-il)piperazin
Identifikatori
CAS broj 146998-34-7 ДаY
ATC kod none
PubChem CID 132787
IUPHAR/BPS 26
ChEMBL CHEMBL49247 ДаY
Hemijski podaci
Formula C21H24N2O2
Molarna masa 336,427 g/mol
  (verify)

S-15535 je fenilpiperazinski lek koji je potentan i visoko selektivan ligand 5-HT1A receptor. On je agonist i antagonist (slab parcijalni agonist) na presinaptičkim i postsinaptičkim 5-HT1A receptorima, respektivno.[1][2][3][4] On ima anksiolitička svojstva.[4][5]

Reference[уреди]

  1. Millan MJ, Rivet JM, Canton H, Lejeune F, Gobert A, Widdowson P, Bervoets K, Brocco M, Peglion JL (1993). „S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist (weak partial agonist) at presynaptic and postsynaptic sites respectively”. Eur J Pharmacol. 230 (1): 99—102. PMID 8381359. doi:10.1016/0014-2999(93)90416-F. 
  2. Millan MJ; Canton H; Gobert A; Lejeune F; Rivet JM; Bervoets K; Brocco M; Widdowson P; Mennini T; Audinot V; et al. (1994). „Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists”. J Pharmacol Exp Ther. 268 (1): 337—352. PMID 8301575. 
  3. Millan MJ, Newman-Tancredi A, Rivet JM, Brocco M, Lacroix P, Audinot V, Cistarelli L, Gobert A (1997). „S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity”. J Pharmacol Exp Ther. 282 (1): 132—147. PMID 9223549. 
  4. 4,0 4,1 Lejeune F, Millan MJ (1998). „Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535”. Synapse. 30 (2): 172—180. PMID 9723787. doi:10.1002/(SICI)1098-2396(199810)30:2<172::AID-SYN7>3.0.CO;2-9. 
  5. Dekeyne A, Brocco M, Adhumeau A, Gobert A, Millan MJ (2000). „The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats. A comparison with other anxiolytic agents”. Psychopharmacology (Berl). 152 (1): 55—66. PMID 11041316. doi:10.1007/s002130000449. 

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