5-Metoksitriptamin

Из Википедије, слободне енциклопедије
5-Metoksitriptamin
5-methoxytryptamine.png
IUPAC ime
2-(5-Methoxy-1H-indol-3-yl)ethanamine
Identifikatori
CAS broj 608-07-1
PubChem CID 1833
IUPHAR/BPS 107
ChemSpider 1767 ДаY
KEGG C05659 ДаY
ChEMBL CHEMBL8165 ДаY
Hemijski podaci
Formula C11H14N2O
Molarna masa 190.242 g/mol
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5-Metoksitriptamin (5-MT, meksamin) je derivat triptamina. On je blisko srodan neurotransmiterima serotoninu i melatoninu. Za 5-MT je pokazano da se prirodno javlja u telu u niskim nivoima.[1] On je proizvod dekarboksilacije melatonina u epifizi.[1]

5-MT deluje kao pun agonist 5-HT1, 5-HT2, 5-HT4, 5-HT6, i 5-HT7 receptora.[2][3][4][5][6][7][8] On nema afinitet za 5-HT3 receptor. Njegov afinitet za 5-HT1E receptor je veoma slab u poređenju sa drugim 5-HT1 receptorima.[5][9]

Vidi još[уреди]

Референце[уреди]

  1. 1,0 1,1 Galzin AM, Eon MT, Esnaud H, Lee CR, Pévet P, Langer SZ (1988). „Day-night rhythm of 5-methoxytryptamine biosynthesis in the pineal gland of the golden hamster (Mesocricetus auratus).”. J Endocrinol. 118 (3): 389—397. doi:10.1677/joe.0.1180389. PMID 2460575. 
  2. Wu PH, Gurevich N, Carlen PL (1988). „Serotonin-1A receptor activation in hippocampal CA1 neurons by 8-hydroxy-2-(di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine.”. Neurosci Lett. 86 (1): 72—76. doi:10.1016/0304-3940(88)90185-1. PMID 2966313. 
  3. Yamada J, Sugimoto Y, Yoshikawa T, Horisaka K (1997). „Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor.”. Eur J Pharmacol. 323 (2-3): 235—240. doi:10.1016/S0014-2999(97)00029-0. PMID 9128844. 
  4. Amemiya N, Hatta S, Takemura H, Ohshika H (1996). „Characterization of the contractile response induced by 5-methoxytryptamine in rat stomach fundus strips.”. Eur J Pharmacol. 318 (2-3): 403—409. doi:10.1016/S0014-2999(96)00777-7. PMID 9016931. 
  5. 5,0 5,1 Craig DA, Eglen RM, Walsh LK, Perkins LA, Whiting RL, Clarke DE (1990). „5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.”. Naunyn Schmiedebergs Arch Pharmacol. 342 (1): 9—16. PMID 2402303. 
  6. Boess FG, Monsma FJ Jr, Carolo C, Meyer V, Rudler A, Zwingelstein C, Sleight AJ (1997). „Functional and radioligand binding characterization of rat 5-HT6 receptors stably expressed in HEK293 cells.”. Neuropharmacology. 36 (4-5): 713—720. doi:10.1016/S0028-3908(97)00019-1. PMID 9225298. 
  7. Hemedah M, Coupar IM, Mitchelson FJ (1999). „[3H]-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum.”. Br J Pharmacol. 126 (1): 179—188. doi:10.1038/sj.bjp.0702293. PMC 1565797Слободан приступ. PMID 10051134. 
  8. Glennon RA, Dukat M, Westkaemper RB (1. 1. 2000). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Приступљено 11. 4. 2008. 
  9. Roth, Brian (2006). The serotonin receptors. Humana Press. стр. 133. ISBN 978-1-58829-568-2, 9781588295682 . 

Литература[уреди]

  • Roth, Brian (2006). The serotonin receptors. Humana Press. стр. 133. ISBN 978-1-58829-568-2, 9781588295682 .