5-Karboksamidotriptamin

Из Википедије, слободне енциклопедије
5-Karboksamidotriptamin
5-Carboxamidotryptamine.png
IUPAC ime
3-(2-aminoethyl)-1H-indole-5-carboxamide
Identifikatori
CAS broj 74885-09-9 ДаY
ATC kod None
PubChem CID 1809
IUPHAR/BPS 4
ChemSpider 1743 ДаY
ChEMBL CHEMBL18840 ДаY
Hemijski podaci
Formula C11H13N3O
Molarna masa 203.240 g/mol
  (verify)

5-Karboksamidotriptamin (5-CT) je triptaminski derivat koji je blisko srodan sa neurotransmiterom serotoninom.

5-CT deluje kao neselektivni pun agonist visokog afiniteta na 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, i 5-HT7 receptore, kao i na 5-HT2, 5-HT3, 5-HT6 receptore sa nižim afinitetom.[1][2][3] On ima neznatan afinitet za 5-HT1E i 5-HT1F receptore.[4] 5-CT se najjače vezuje za 5-HT1A receptor i nekad se smatralo da je selektivan za njega.[5][6]

Vidi još[уреди]

Literatura[уреди]

  1. Yamada J, Sugimoto Y, Noma T, Yoshikawa T (1998). „Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats.”. Eur J Pharmacol. 359 (1): 81—86. PMID 9831297. doi:10.1016/S0014-2999(98)00617-7. 
  2. Wright, CE; Angus, JA (1989). „5-carboxamidotryptamine elicits 5-HT2 and 5-HT3 receptor-mediated cardiovascular responses in the conscious rabbit: evidence for 5-HT release from platelets.”. Journal of cardiovascular pharmacology. 13 (4): 557—64. PMID 2470992. 
  3. Glennon RA, Dukat M, Westkaemper RB (01. 01. 2000). „Serotonin Receptor Subtypes and Ligands”. American College of Neurophyscopharmacology. Приступљено 11. 04. 2008. 
  4. Stanton JA, Middlemiss DN, Beer MS (1996). „Autoradiographic localization of 5-CT-insensitive 5-HT1-like recognition sites in guinea pig and rat brain.”. Neuropharmacology. 35 (2): 223—229. PMID 8734492. doi:10.1016/0028-3908(95)00178-6. 
  5. Thomas, DR; Middlemiss, DN; Taylor, SG; Nelson, P; Brown, AM (1999). „5-CT stimulation of adenylyl cyclase activity in guinea-pig hippocampus: evidence for involvement of 5-HT7 and 5-HT1A receptors.”. British journal of pharmacology. 128 (1): 158—64. PMC 1571602Слободан приступ. PMID 10498847. doi:10.1038/sj.bjp.0702759. 
  6. Saxena, PR; Lawang, A (1985). „A comparison of cardiovascular and smooth muscle effects of 5-hydroxytryptamine and 5-carboxamidotryptamine, a selective agonist of 5-HT1 receptors.”. Archives internationales de pharmacodynamie et de therapie. 277 (2): 235—52. PMID 2933009.