SDZ SER-082

Из Википедије, слободне енциклопедије
SDZ SER-082
SDZSER082 structure.png
IUPAC ime
(+)-cis 4,5,7a,8,9,10,11,11a-oktahidro-7H-10-metilindolo[1,7-bc][2,6]-naftiridin
Identifikatori
CAS broj 141474-54-6 ДаY
ATC kod none
PubChem CID 9859407
Hemijski podaci
Formula C15H20N2
Molarna masa 228,332 g/mol
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SDZ SER-082 je lek koji deluje kao mešoviti antagonist za 5-HT2B i 5-HT2C serotoninske receptore, sa dobrom selektivnošću za druge tipove serotoninskog receptora i malom preferencijom za 5-HT2C u odnosu na 5-HT2B.[1] On je korišten u životinjskim studijama uticaja dejstva različitih 5-HT2 podtipova,[2][3][4] i kako oni utiču na efekte drugih lekova poput kokaina.[5][6][7]

Reference[уреди]

  1. Nozulak J, Kalkman HO, Floerscheim P, Hoyer D, Schoeffter P, Buerki HR. (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]- naphthyridine: A 5-HT2C/2B Receptor Antagonist with Low 5-HT2A Receptor Affinity. Journal of Medicinal Chemistry. 1995 Jan;38(1):28-33. doi:10.1021/jm00001a007
  2. Mora PO, Netto CF, Graeff FG (1997). „Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze”. Pharmacology, Biochemistry, and Behavior 58 (4): 1051—7. doi:10.1016/S0091-3057(97)00057-9. PMID 9408213. 
  3. Dave KD, Harvey JA, Aloyo VJ (2002). „A novel behavioral model that discriminates between 5-HT2A and 5-HT2C receptor activation”. Pharmacology, Biochemistry, and Behavior 72 (1-2): 371—8. doi:10.1016/S0091-3057(01)00767-5. PMID 11900808. 
  4. Hawkins MF, Uzelac SM, Hearn JK, Baumeister AA (2008). „Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat”. Pharmacology, Biochemistry, and Behavior 90 (4): 632—9. doi:10.1016/j.pbb.2008.05.006. PMID 18572227. 
  5. Filip M, Bubar MJ, Cunningham KA (2004). „Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses”. The Journal of Pharmacology and Experimental Therapeutics 310 (3): 1246—54. doi:10.1124/jpet.104.068841. PMID 15131246. 
  6. Filip M (2005). „Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats”. Pharmacological Reports : PR 57 (1): 35—46. PMID 15849375. 
  7. Filip M, Bubar MJ, Cunningham KA (2006). „Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats”. Psychopharmacology 183 (4): 482—9. doi:10.1007/s00213-005-0197-y. PMID 16261316. 

Spoljašnje veze[уреди]