SDZ SER-082

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SDZ SER-082
SDZSER082 structure.png
IUPAC ime
(+)-cis 4,5,7a,8,9,10,11,11a-oktahidro-7H-10-metilindolo[1,7-bc][2,6]-naftiridin
Identifikatori
CAS broj 141474-54-6 ДаY
ATC kod none
PubChem CID 9859407
Hemijski podaci
Formula C15H20N2
Molarna masa 228,332 g/mol
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SDZ SER-082 je lek koji deluje kao mešoviti antagonist za 5-HT2B i 5-HT2C serotoninske receptore, sa dobrom selektivnošću za druge tipove serotoninskog receptora i malom preferencijom za 5-HT2C u odnosu na 5-HT2B.[1] On je korišten u životinjskim studijama uticaja dejstva različitih 5-HT2 podtipova,[2][3][4] i kako oni utiču na efekte drugih lekova poput kokaina.[5][6][7]

Reference[уреди]

  1. Nozulak J, Kalkman HO, Floerscheim P, Hoyer D, Schoeffter P, Buerki HR. (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]- naphthyridine: A 5-HT2C/2B Receptor Antagonist with Low 5-HT2A Receptor Affinity. Journal of Medicinal Chemistry. 1995 Jan;38(1):28-33. doi:10.1021/jm00001a007
  2. Mora PO, Netto CF, Graeff FG (1997). „Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze”. Pharmacology, Biochemistry, and Behavior. 58 (4): 1051—7. PMID 9408213. doi:10.1016/S0091-3057(97)00057-9. 
  3. Dave KD, Harvey JA, Aloyo VJ (2002). „A novel behavioral model that discriminates between 5-HT2A and 5-HT2C receptor activation”. Pharmacology, Biochemistry, and Behavior. 72 (1-2): 371—8. PMID 11900808. doi:10.1016/S0091-3057(01)00767-5. 
  4. Hawkins MF, Uzelac SM, Hearn JK, Baumeister AA (2008). „Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat”. Pharmacology, Biochemistry, and Behavior. 90 (4): 632—9. PMID 18572227. doi:10.1016/j.pbb.2008.05.006. 
  5. Filip M, Bubar MJ, Cunningham KA (2004). „Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses”. The Journal of Pharmacology and Experimental Therapeutics. 310 (3): 1246—54. PMID 15131246. doi:10.1124/jpet.104.068841. 
  6. Filip M (2005). „Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats”. Pharmacological Reports : PR. 57 (1): 35—46. PMID 15849375. 
  7. Filip M, Bubar MJ, Cunningham KA (2006). „Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats”. Psychopharmacology. 183 (4): 482—9. PMID 16261316. doi:10.1007/s00213-005-0197-y. 

Spoljašnje veze[уреди]