CSP-2503

CSP-2503
IUPAC ime
	2-[(4-naftalen-1-ilpiperazin-1-il)metil]heksahidropirolo[1,2-a]pirazin-1,4-dion
Identifikatori
ATC kod	none
PubChem	CID 10317515
ChemSpider	8492979
ChEMBL	CHEMBL285066
Hemijski podaci
Formula	C22H26N4O2
Molarna masa	378,47 g/mol
	SMILES O=C4N5CCCC5C(=O)N(CN3CCN(c2c1ccccc1ccc2)CC3)C4; ;
	InChI InChI=1S/C22H26N4O2/c27-21-15-25(22(28)20-9-4-10-26(20)21)16-23-11-13-24(14-12-23)19-8-3-6-17-5-1-2-7-18(17)19/h1-3,5-8,20H,4,9-16H2 ; Key:CTZWGZSINBFHFD-UHFFFAOYSA-N ;

CSP-2503 je potentan i selektivan agonist 5-HT_1A receptora, i antagonist 5-HT_2A receptor i 5-HT₃ receptora.^[1] On je prvi put sintetisan 2003 koristeći dizajn baziran na računarskom modelu i QSAR studijama.^[2]^[3] U istraživanjima na pacovima, CSP-2503 je pokazao anksiolitičko dejstvo, te je smatra da može da služi kao potencijalni tretman za anksioznost kod ljudi, sa multimodalnim mehanizmom dejstva.^[1]

References

^ ^а ^б Delgado M; Caicoya AG; Greciano V; et al. (2005). „Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors”. European Journal of Pharmacology. 511 (1): 9—19. PMID 15777774. doi:10.1016/j.ejphar.2005.01.032.
^ López-Rodríguez ML; Morcillo MJ; Fernández E; et al. (2003). „Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist”. Bioorganic & Medicinal Chemistry Letters. 13 (8): 1429—32. PMID 12668005. doi:10.1016/S0960-894X(03)00160-4.
^ López-Rodríguez ML; Morcillo MJ; Fernández E; et al. (2005). „Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors”. Journal of Medicinal Chemistry. 48 (7): 2548—58. PMID 15801844. doi:10.1021/jm048999e.