SB-204,741

Из Википедије, слободне енциклопедије
SB-204,741
SB-204,741 structure.png
IUPAC ime
N-(1-Metil-1H-indol-5-il)-N'-(3-metilizotiazol-5-il)ureja
Identifikatori
CAS broj 152239-46-8 ДаY
ATC kod none
PubChem CID 3277600
IUPHAR/BPS 221
Sinonimi SB-204,741
Hemijski podaci
Formula C14H14N4OS
Molarna masa 286,352 g/mol
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SB-204,741 je lek koji deluje kao potentan i selektivan antagonist na serotoninskom 5-HT2B receptoru, sa oko 135x selektivnošću u odnosu na blisko srodni 5-HT2C receptor, i još većom u odnosu na 5-HT2A receptor.[1] On se koristi u naučnim istraživanjima za ispitivanje funkcije 5-HT2B receptora.[2][3][4][5]

Reference[уреди]

  1. Forbes, IT; Jones, GE; Murphy, OE; Holland, V; Baxter, GS (1995). „N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT2B receptor antagonist”. Journal of Medical Chemistry. 38 (6): 855—7. doi:10.1021/jm00006a001. PMID 7699699. 
  2. Glusa, E; Pertz, HH (2000). „Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT2B receptors”. British Journal of Pharmacology. 130 (3): 692—8. doi:10.1038/sj.bjp.0703341. PMC 1572101слободно за читање. PMID 10821800. 
  3. Holohean, AM; Hackman, JC (2004). „Mechanisms intrinsic to 5-HT2B receptor-induced potentiation of NMDA receptor responses in frog motoneurones”. British Journal of Pharmacology. 143 (3): 351—60. doi:10.1038/sj.bjp.0705935. PMC 1575347слободно за читање. PMID 15339859. 
  4. Papageorgiou, A; Denef, C (2007). „Stimulation of growth hormone release by 5-hydroxytryptamine (5-HT) in cultured rat anterior pituitary cell aggregates: evidence for mediation by 5-HT2B, 5-HT7, 5-HT1B, and ketanserin-sensitive receptors”. Endocrinology. 148 (9): 4509—22. doi:10.1210/en.2007-0034. PMID 17584957. 
  5. Wouters, MM; Gibbons, SJ; Roeder, JL; Distad, M; Ou, Y; Strege, PR; Szurszewski, JH; Farrugia, G (2007). „Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors”. Gastroenterology. 133 (3): 897—906. doi:10.1053/j.gastro.2007.06.017. PMID 17854596. 

Spoljašnje veze[уреди]