Volinanserin

Из Википедије, слободне енциклопедије
Volinanserin
MDL-100,907 structure.png
IUPAC ime
(R)-(2,3-dimetoksifenil)-[1-[2-(4-fluorofenil)etil]-4-piperidil]metanol
Identifikatori
CAS broj 139290-65-6 ДаY
ATC kod none
PubChem CID 5311271
IUPHAR/BPS 185
ChemSpider 4470782
UNII EW71EE171J ДаY
ChEMBL CHEMBL74355
Hemijski podaci
Formula C22H28FNO3
Molarna masa 373,46 g/mol

Volinanserin (MDL-100,907) je visoko selektivan antagonist 5-HT2A receptor. On je u širokoj upotrebi u naučnim istraživanjima za istraživanje funkcije 5-HT2A receptora.[1][2][3] Volinanserin se isto tako ispituje kao potencijalni antipsihotik, antidepresiv i tretman za insomniju.[4][5][6]

Reference[уреди]

  1. Schmidt CJ, Fadayel GM, Sullivan CK, Taylor VL (1992). „5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine”. European Journal of Pharmacology 223 (1): 65—74. doi:10.1016/0014-2999(92)90819-P. PMID 1362159. 
  2. Herth MM, Kramer V, Piel M, Palner M, Riss PJ, Knudsen GM, Rösch F (2009). „Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET”. Bioorganic & Medicinal Chemistry 17 (8): 2989—3002. doi:10.1016/j.bmc.2009.03.021. PMID 19329329. 
  3. Nic Dhonnchadha BA, Fox RG, Stutz SJ, Rice KC, Cunningham KA (2009). „Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model”. Behavioral Neuroscience 123 (2): 382—96. doi:10.1037/a0014592. PMID 19331461. 
  4. Offord SJ, Wong DF, Nyberg S (1999). „The role of positron emission tomography in the drug development of M100907, a putative antipsychotic with a novel mechanism of action”. Journal of Clinical Pharmacology. Suppl: 17S—24S. PMID 10434243. 
  5. Marek GJ, Martin-Ruiz R, Abo A, Artigas F (2005). „The selective 5-HT2A receptor antagonist M100907 enhances antidepressant-like behavioral effects of the SSRI fluoxetine”. Neuropsychopharmacology 30 (12): 2205—15. doi:10.1038/sj.npp.1300762. PMID 15886717. 
  6. Teegarden BR, Al Shamma H, Xiong Y (2008). „5-HT(2A) inverse-agonists for the treatment of insomnia”. Current Topics in Medicinal Chemistry 8 (11): 969—76. doi:10.2174/156802608784936700. PMID 18673166. 

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