Spiramid

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Spiramid
AMI-193 structure.png
IUPAC ime
8-[3-(4-Fluorofenoksi)propil]-1-fenil-1,3,8-triazaspiro[4,5]dekan-4-o
Identifikatori
CAS broj 510-74-7 ДаY
ATC kod none
PubChem CID 68186
IUPHAR/BPS 175
UNII 471LF4O004 ДаY
Hemijski podaci
Formula C22H27FN3O2
Molarna masa 384,466 g/mol
  (verify)

Spiramid (AMI-193) je selektivni antagonist 5-HT2A, 5-HT1A, i D2 receptor. On ima neznatan afinitet za 5-HT2C receptor.[1][2][3]

Reference[уреди]

  1. Czoty PW, Howell LL (2000). „Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, in the squirrel monkey”. Pharmacology, Biochemistry, and Behavior. 67 (2): 257—64. PMID 11124389. doi:10.1016/S0091-3057(00)00321-X. 
  2. Luparini MR, Garrone B, Pazzagli M, Pinza M, Pepeu G (2004). „A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone”. Progress in Neuro-psychopharmacology & Biological Psychiatry. 28 (7): 1117—27. PMID 15610924. doi:10.1016/j.pnpbp.2004.05.046. 
  3. Hamada K, Yoshida M, Isayama H, Yagi Y, Kanazashi S, Kashihara Y, Takeuchi K, Yamaguchi I (2007). „Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice”. Journal of Pharmacological Sciences. 105 (3): 240—50. PMID 17965538. doi:10.1254/jphs.FP0071049. 

Spoljašnje veze[уреди]