Adatanserin

Из Википедије, слободне енциклопедије
Adatanserin
Adatanserin.png
IUPAC ime
N-[2-(4-pirimidin-2-ilpiperazin-1-il)etil]adamantan-1-karboksamid
Identifikatori
CAS broj 127266-56-2 ДаY
ATC kod none
PubChem CID 130918
ChemSpider 115774 ДаY
UNII W5U6WQM26H ДаY
Hemijski podaci
Formula C21H31N5O
Molarna masa 369,50 g/mol
  (verify)

Adatanserin (WY-50,324, SEB-324) je mešoviti 5-HT1A receptor parcijalni agonist i antagonist 5-HT2A i 5-HT2C receptora.[1][2][3] On je razvijan kao kao antidepresiv ali je razboj zaustavljen.[3][4]

Adantaserin poseduje neuroprotektivna svojstva protiv ishemijom indukovane glutamatergičke ekscitotoksičnosti. Taj efekat je posredovan blokadom 5-HT2A receptora.[5]

Vidi još[уреди]

Reference[уреди]

  1. Singh A, Lucki I (1993). „Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors”. Neuropharmacology. 32 (4): 331—40. PMID 8497336. doi:10.1016/0028-3908(93)90153-T. 
  2. Kleven MS, Koek W (1996). „Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon”. The Journal of Pharmacology and Experimental Therapeutics. 276 (2): 388—97. PMID 8632301. 
  3. 3,0 3,1 Abou-Gharbia MA; Childers WE; Fletcher H; et al. (1999). „Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents”. Journal of Medicinal Chemistry. 42 (25): 5077—94. PMID 10602693. doi:10.1021/jm9806704. 
  4. Stahl, S. M. (2000). Essential psychopharmacology: neuroscientific basis and practical application. Cambridge, UK: Cambridge University Press. ISBN 0-521-64615-4. 
  5. Dawson LA, Galandak J, Djali S (2002). „Attenuation of ischemic efflux of endogenous amino acids by the novel 5-HT(1A)/5-HT(2) receptor ligand adatanserin”. Neurochemistry International. 40 (3): 203—9. PMID 11741003. doi:10.1016/S0197-0186(01)00082-1. 

Literatura[уреди]