Flestolol

Flestolol
Nazivi
	IUPAC naziv 3[1-(Karbamoilamino)-2-metil-2-propanil]amino2-hidroksipropil 2-fluorobenzoat
Identifikacija
CAS broj	87721-62-8 ;
3D model (Jmol)	interaktivna slika;
ChemSpider	50465;
KEGG	D04190;
PubChem C ID	55885;
UNII	LI02075E1W ;
	SMILES CC(C)(CNC(=O)N)NCC(COC(=O)C1=CC=CC=C1F)O; ; ; ; ; ;
Svojstva
Hemijska formula	C15H22FN3O4
Molarna masa	327,36 g·mol−1
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	Reference infokutije

Flestolol je kratkotrajni agonist beta adrenergijskog receptora.^[4]

Sinteza[уреди | уреди извор]

Acilacijom glicidola (2) hloridom kiseline 1 nastaje estar 3. Reakcija tog intermedijera sa aminom 4, dobijenog reakcijom 1,1-dimetiletilendiamina sa urejom, daje flestolol (5).

Reference[уреди | уреди извор]

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Quon, CY; Stampfli, HF (1993). „Biochemical characterization of flestolol esterase”. Research communications in chemical pathology and pharmacology. 81 (3): 309—22. PMID 8235065.
^ Kam, Sheung Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; O'Donnell, John P.; Stampfli, Herman F.; Sum, Check Y.; Anderson, William G. (1984). „[(Arylcarbonyl)oxy]propanolamines. 1. Novel .beta.-blockers with ultrashort duration of action”. Journal of Medicinal Chemistry. 27 (8): 1007. PMID 6146718. doi:10.1021/jm00374a013.

[1] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[3] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[4] Quon, CY; Stampfli, HF (1993). „Biochemical characterization of flestolol esterase”. Research communications in chemical pathology and pharmacology. 81 (3): 309—22. PMID 8235065.

[5] Kam, Sheung Tsam; Matier, William L.; Mai, Khuong X.; Barcelon-Yang, Cynthia; Borgman, Robert J.; O'Donnell, John P.; Stampfli, Herman F.; Sum, Check Y.; Anderson, William G. (1984). „[(Arylcarbonyl)oxy]propanolamines. 1. Novel .beta.-blockers with ultrashort duration of action”. Journal of Medicinal Chemistry. 27 (8): 1007. PMID 6146718. doi:10.1021/jm00374a013.

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