Tolazolin

Tolazolin
IUPAC ime
	2-benzil-4,5-dihidro-1H-imidazol
Klinički podaci
Drugs.com	Internacionalno ime leka
Način primene	IV
Identifikatori
CAS broj	59-98-3
ATC kod	C04AB02 (WHO) M02AX02 QV03AB94
PubChem	CID 5504
DrugBank	DB00797
ChemSpider	5303
UNII	CHH9H12AQ3
KEGG	D08614
ChEBI	CHEBI:28502
ChEMBL	CHEMBL770
Hemijski podaci
Formula	C10H12N2
Molarna masa	160,216 g/mol
	SMILES N\1=C(\NCC/1)Cc2ccccc2; ;
	InChI InChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12) ; Key:JIVZKJJQOZQXQB-UHFFFAOYSA-N ;

Tolazolin je neselektivni kompetitivni antagonist α-adrenergičkog receptora. On je vazodilatator koji se koristi za tretiranje spazama perifernih krvnih sudova (kao u akrocijanozi). On je takođe uspešno korišćen kao antidot za poništavanje jake periferne vazokonstrikcije koja se može javiti usled predoziranja pojedinih agonista 5-HT_2A receptora kao što su LSD, DOB i Bromo-DragonFLY, koji mogu da dovedu do gangrene ako se ne tretiraju.^[1]^[2]

On se najčešće koristi u veterini, za poništavanje ksilazinom indukovane sedacije.^[3]^[4]

Hemija

Tolazolin, 2-benzil-2-imidazolin, se može sintetisati putem heterociklizacije ethil ester iminofenzilsirćetne kiseline sa etilen diaminom. Struktura tolazolina je veoma slična sa α-adrenergičkim agonistima, koji su antiedemski simpatomimetici.^[5]^[6]^[7]^[8]

Reference

^ Bowen JS, Davis GB, Kearney TE, Bardin J. Diffuse vascular spasm associated with 4-bromo-2,5-dimethoxyamphetamine ingestion. Journal of the American Medical Association 1983 Mar 18;249(11):1477-9. PMID 6827726
^ Thorlacius K, Borna C, Personne M. Bromo-dragon fly--life-threatening drug. Can cause tissue necrosis as demonstrated by the first described case. (Swedish) Lakartidningen. 2008 Apr 16-22;105(16):1199-200. PMID 18522262
^ Boothe, DM (2001). „Anticonvulsant drugs and analeptic agents”. Ур.: Adams, HR. Veterinary pharmacology and therapeutics. Ames: Iowa State University Press. ISBN 0-8138-1743-9. Retrieved September 8, 2008 through Google Book Search.
^ Hall LW, Clarke KW, Trim CM (2001). „Principles of sedation, analgesia and premedication”. Veterinary anaesthesia. Philadelphia: W.B. Saunders. ISBN 0-7020-2035-4.
^ A. Sonn, U.S. Patent 2.161.938 (1939).
^ W. Wustrow, P. Herold, DE 615527 (1934).
^ M. Hartmann, H.O. Isler, DE 687196 (1938).
^ N. Guenter, DE 3043562 (1982).

Literatura

Boothe, DM (2001). „Anticonvulsant drugs and analeptic agents”. Ур.: Adams, HR. Veterinary pharmacology and therapeutics. Ames: Iowa State University Press. ISBN 0-8138-1743-9. Retrieved September 8, 2008 through Google Book Search.
Hall LW, Clarke KW, Trim CM (2001). „Principles of sedation, analgesia and premedication”. Veterinary anaesthesia. Philadelphia: W.B. Saunders. ISBN 0-7020-2035-4.

Spoljašnje veze

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Bowen JS, Davis GB, Kearney TE, Bardin J. Diffuse vascular spasm associated with 4-bromo-2,5-dimethoxyamphetamine ingestion. Journal of the American Medical Association 1983 Mar 18;249(11):1477-9. PMID 6827726

[2] Thorlacius K, Borna C, Personne M. Bromo-dragon fly--life-threatening drug. Can cause tissue necrosis as demonstrated by the first described case. (Swedish) Lakartidningen. 2008 Apr 16-22;105(16):1199-200. PMID 18522262

[3] Boothe, DM (2001). „Anticonvulsant drugs and analeptic agents”. Ур.: Adams, HR. Veterinary pharmacology and therapeutics. Ames: Iowa State University Press. ISBN 0-8138-1743-9. Retrieved September 8, 2008 through Google Book Search.

[4] Hall LW, Clarke KW, Trim CM (2001). „Principles of sedation, analgesia and premedication”. Veterinary anaesthesia. Philadelphia: W.B. Saunders. ISBN 0-7020-2035-4.

[5] A. Sonn, U.S. Patent 2.161.938 (1939).

[6] W. Wustrow, P. Herold, DE 615527 (1934).

[7] M. Hartmann, H.O. Isler, DE 687196 (1938).

[8] N. Guenter, DE 3043562 (1982).

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