Deterenol

Deterenol
IUPAC ime
	4-[1-hidroksi-2-(propan-2-ilamino)etil]fenol
Klinički podaci
Prodajno ime	Betafrin
Identifikatori
CAS broj	7376-66-1
PubChem	CID 23843
ChemSpider	22290
UNII	BR971OUC9M
KEGG	D03700
ChEMBL	CHEMBL109378
Sinonimi	Izopropilnorsinefrin, izopropiloktopamin
Hemijski podaci
Formula	C11H17NO2
Molarna masa	195,26 g·mol−1
	SMILES CC(C)NCC(C1=CC=C(C=C1)O)O; ;
	InChI InChI=1S/C11H17NO2/c1-8(2)12-7-11(14)9-3-5-10(13)6-4-9/h3-6,8,11-14H,7H2,1-2H3; Key:MPCPSVWSWKWJLO-UHFFFAOYSA-N;

Deterenol (takođe poznat kao izopropilnorsinefrin i izopropiloktopamin; trgovačko ime betafrin) je stimulatski lek koji deluje kao beta agonist. Pronađen je kao sastojak proizvoda dijetetskih suplemenata, ali je zabranjen u većini zemalja zbog rizika od srčanog udara.^[1]^[2]^[3]^[4]^[5]

Reference[уреди | уреди извор]

^ Anderson WG (јун 1983). „The sympathomimetic activity of N-isopropyloctopamine in vitro”. The Journal of Pharmacology and Experimental Therapeutics. 225 (3): 553—8. PMID 6306210.
^ Mercader J, Wanecq E, Chen J, Carpéné C (септембар 2011). „Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium”. Journal of Physiology and Biochemistry. 67 (3): 443—52. PMID 21336650. S2CID 22449550. doi:10.1007/s13105-011-0078-2.
^ Venhuis B, Keizers P, van Riel A, de Kaste D (јун 2014). „A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events”. Drug Testing and Analysis. 6 (6): 578—81. PMID 24802503. doi:10.1002/dta.1664.
^ Zhao J, Wang M, Avula B, Khan IA (март 2018). „Detection and quantification of phenethylamines in sports dietary supplements by NMR approach”. Journal of Pharmaceutical and Biomedical Analysis. 151: 347—355. PMID 29413984. S2CID 46837518. doi:10.1016/j.jpba.2018.01.025 .
^ Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ (март 2021). „Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine”. Clinical Toxicology. 59 (11): 975—981. PMID 33755516. doi:10.1080/15563650.2021.1894333 .

[1] Anderson WG (јун 1983). „The sympathomimetic activity of N-isopropyloctopamine in vitro”. The Journal of Pharmacology and Experimental Therapeutics. 225 (3): 553—8. PMID 6306210.

[2] Mercader J, Wanecq E, Chen J, Carpéné C (септембар 2011). „Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium”. Journal of Physiology and Biochemistry. 67 (3): 443—52. PMID 21336650. S2CID 22449550. doi:10.1007/s13105-011-0078-2.

[3] Venhuis B, Keizers P, van Riel A, de Kaste D (јун 2014). „A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events”. Drug Testing and Analysis. 6 (6): 578—81. PMID 24802503. doi:10.1002/dta.1664.

[4] Zhao J, Wang M, Avula B, Khan IA (март 2018). „Detection and quantification of phenethylamines in sports dietary supplements by NMR approach”. Journal of Pharmaceutical and Biomedical Analysis. 151: 347—355. PMID 29413984. S2CID 46837518. doi:10.1016/j.jpba.2018.01.025 .

[5] Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ (март 2021). „Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine”. Clinical Toxicology. 59 (11): 975—981. PMID 33755516. doi:10.1080/15563650.2021.1894333 .

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