Atiprosin

Atiprosin
IUPAC ime
	(4aR,12bS)-1-etil-12-metil-4-(propan-2-il)-1,2,3,4,4a,5,6,12b-oktahidropirazino[2',3':3,4]pirido[1,2-a]indol
Klinički podaci
Način primene	Oralno
Pravni status
Pravni status	Nije kontrolisan;
Identifikatori
CAS broj	89303-63-9 []
ATC kod	none
PubChem	CID 71770
ChemSpider	64808
UNII	ALS52889WF
Hemijski podaci
Formula	C20H29N3
Molarna masa	311,46 g/mol
	SMILES n23c1ccccc1c(c2[C@H]4N(CCN([C@@H]4CC3)C(C)C)CC)C; ;
	InChI InChI=1S/C20H29N3/c1-5-21-12-13-22(14(2)3)18-10-11-23-17-9-7-6-8-16(17)15(4)19(23)20(18)21/h6-9,14,18,20H,5,10-13H2,1-4H3/t18-,20+/m1/s1 ; Key:WXNVFYIBELASJW-QUCCMNQESA-N ;

Atiprosin (AY-28,228) je antihipertenzivni lek koji se koristi kao selektivni antagonist α₁-adrenergičkog receptora.^[1]^[2]^[3]^[4] On takođe poseduje izvesnu antihistaminsku aktivnost, mada je ona slaba.^[3] On nije plasiran na tržište.^[1]

Sinteza[уреди | уреди извор]

Jedan od mogućih sintetičkih puteva je^[5]:

^ ^а ^б Triggle, David J. (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 978-0-412-46630-4.
^ Jirkovsky I, Santroch G, Baudy R, Oshiro G (1987). „Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents”. Journal of Medicinal Chemistry. 30 (2): 388—94. PMID 3806618. doi:10.1021/jm00385a022.
^ ^а ^б Grimes D; Rimele TJ; Henry DE; et al. (1987). „In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound”. Journal of Cardiovascular Pharmacology. 10 (3): 249—58. PMID 2444771. doi:10.1097/00005344-198709000-00001.
^ Oshiro G, Wojdan A, Klein M, Metcalf G (1987). „Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys”. Journal of Cardiovascular Pharmacology. 10 (3): 341—9. PMID 2444784. doi:10.1097/00005344-198709000-00014.
^ Jirkovsky, Ivo; George Santroch; Reinhardt Baudy; George Oshiro (1987). „Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents”. Journal of Medical Chemistry. 30 (2): 388—394. PMID 3806618. doi:10.1021/jm00385a022.