ICI-118,551

Из Википедије, слободне енциклопедије
ICI-118,551
ICI 118551.svg
Nazivi
IUPAC naziv
3-(izopropilamino)-1-[(7-metil-4-indanil)oksi]butan-2-ol
Identifikacija
3D model (Jmol)
MeSH ICI+118551
Svojstva
C17H27NO2
Molarna masa 277,402 g/mol
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
ДаY verifikuj (šta je ДаYНеН ?)
Reference infokutije

ICI-118,551 je selektivni antagonist beta-22) adrenergičkog receptora.[3][4] ICI se vezuje za β2 receptor sa više od sto puta većim afinitetom nego za β1 ili β3 receptor.[5][6] Kompanija Imperijalne hemijske industrije je razvila ovo jedinjenje.

Reference[уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  edit
  2. Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Hillman KL, Doze VA, Porter JE (2005). „Functional characterization of the beta-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus”. The Journal of Pharmacology and Experimental Therapeutics. 314 (2): 561—7. PMID 15908513. doi:10.1124/jpet.105.084947. 
  4. Summerhill S, Stroud T, Nagendra R, Perros-Huguet C, Trevethick M (2008). „A cell-based assay to assess the persistence of action of agonists acting at recombinant human beta(2) adrenoceptors”. Journal of Pharmacological and Toxicological Methods. 58 (3): 189—97. PMID 18652905. doi:10.1016/j.vascn.2008.06.003. 
  5. Mauriège P, De Pergola G, Berlan M, Lafontan M (1988). „Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic binding sites on human fat cell membranes with highly selective beta-1 antagonists”. Journal of Lipid Research. 29 (5): 587—601. PMID 2900871. 
  6. Emorine LJ; Marullo S; Briend-Sutren MM; et al. (1989). „Molecular characterization of the human beta 3-adrenergic receptor”. Science. 245 (4922): 1118—21. PMID 2570461. doi:10.1126/science.2570461. 

Spoljašnje veze[уреди]