Denopamin

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Denopamin
Denopamine.png
IUPAC ime
4-[(1S)-2-[2-(3,4-dimetoksifenil)etilamino]-1-hidroksietil]Fenol
Klinički podaci
Drugs.com Internacionalno ime leka
Način primene Oralno
Pravni status
Pravni status
  • Rx-only
Identifikatori
CAS broj 71771-90-9 ДаY
ATC kod none
PubChem CID 71754
IUPHAR/BPS 534
ChemSpider 64795
UNII V5F60UPD8P ДаY
KEGG D02614
Hemijski podaci
Formula C18H23NO4
Molarna masa 317,37 g/mol

Denopamin je kardiotonični lek koji deluje kao agonist beta-1 adrenergičkog receptora.[1] On se koristi u lečenju angine[2] i potencionalno može da nađe primenu u tretmanu zatajenja srca[3] i čišćenja edama pluća.[4]

Reference[уреди]

  1. Ishide T. Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator. Current Medical Research and Opinion. 2002;18(7):407-13. PMID 12487507
  2. Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, Ishihara T, Hanafusa T. Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment. International Journal of Cardiology. 2006 Apr 4;108(2):281-3. PMID 15913812
  3. Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S. Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart. Journal of the American College of Cardiology. 1998 Sep;32(3):808-15. doi:10.1016/S0735-1097(98)00314-3 PMID 9741531
  4. Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Inoue M, Watanabe Y. Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs. Japanese Journal of Pharmacology. 2001 Feb;85(2):161-6. doi:10.1254/jjp.85.161 PMID 11286398

Spoljašnje veze[уреди]