4-Metoksi-N, N-dimetiltriptamin (4-MeO-DMT), je triptaminskiderivat koji deluje u životinjskim modelima na sličan način sa srodnim halucinogenim triptaminskim lekovima, mada sa znatno nižom potencijom od 5-MeO-DMT i 4-hidroksi-DMT (psilocina).[1][2][3][4] Homolog dužeg lanca 4-MeO-DET nije aktivan kod ljudi u dozama do 30 mg oralno ili pušenjem. Klinička ispitivanja su pokazala da je njegov izomer 4-MeO-MiPT aktivan u maloj meri.[5]
^Glennon RA, Young R, Benington F, Morin RD (1982). „Hallucinogens as discriminative stimuli: a comparison of 4-OMe DMT and 5-OMe DMT with their methythio counterparts”. Life Sciences. 30 (5): 465—7. PMID6801410. doi:10.1016/0024-3205(82)90463-5.
^Kline TB, Benington F, Morin RD, Beaton JM (1982). „Structure-activity relationships in potentially hallucinogenic N, N-dialkyltryptamines substituted in the benzene moiety”. Journal of Medicinal Chemistry. 25 (8): 908—13. PMID7120280. doi:10.1021/jm00350a005.
^Kline TB, Benington F, Morin RD, Beaton JM, Glennon RA, Domelsmith LN, Houk KN, Rozeboom MD (1982). „Structure-activity relationships for hallucinogenic N, N-dialkyltryptamines: photoelectron spectra and serotonin receptor affinities of methylthio and methylenedioxy derivatives”. Journal of Medicinal Chemistry. 25 (11): 1381—3. PMID6815326. doi:10.1021/jm00353a021.
^Nichols DE; Glennon RA (1984). Medicinal Chemistry and Structure-Activity Relationships of Hallucinogens, in Hallucinogens, Neurochemical, Behavioral, and Clinical Perspectives. Raven Press. стр. 95—142. ISBN978-0-89004-990-7.
