Ajmalicin

Ajmalicin
IUPAC ime
	metil estar (19α)-16,17-didehidro- 19-metiloksajohimban- 16-karboksilne kiseline
Klinički podaci
Način primene	Oralno
Pravni status
Pravni status	℞ (Prescription only);
Identifikatori
CAS broj	483-04-5
ATC kod	none
PubChem	CID 251561
ChemSpider	390541
ChEMBL	CHEMBL123325
Hemijski podaci
Formula	C21H24N2O3
Molarna masa	352,43 g/mol
	SMILES O=C(OC)\C4=C\OC(C5CN3CCc1c(nc2ccccc12)C3CC45)C; ;
	InChI InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1 ; Key:GRTOGORTSDXSFK-XJTZBENFSA-N ;

Ajmalicin (δ-johimbin, raubazin) je antihipertenziv koji se koristi kao tretman za visoki krvni pritisak.^[1] On je bio u prodaji pod raznim imenima, neka od kojih su: Card-Lamuran, Circolene, Cristanyl, Duxil, Duxor, Hydroxysarpon, Iskedyl, Isosarpan, Isquebral, Lamuran, Melanex, Saltucin Co, Salvalion, i Sarpan.^[1] On je isto tako alkaloid koji je prirodno javlja u raznim biljkama kao što su Rauwolfia spp., Catharanthus roseus, i Mitragyna speciosa.^[1]^[2]^[3]

Ajmalicin je strukturno srodan sa johimbinom, rauvolscinom, i drugim johimbanskim derivatima. Poput korinantina, on deluje kao antagonist α₁-adrenergičkog receptora. On je znatno manje aktivan na α₂-adrenergičkim receptorima, iz čega proizilazi njegovo hipotenzivno dejstvo.^[1]^[4]

Vidi još[uredi | uredi izvor]

Reference[uredi | uredi izvor]

^ ^а ^б ^в ^г Wink, Michael; Roberts, M. W. (1998). Alkaloids: biochemistry, ecology, and medicinal applications. New York: Plenum Press. ISBN 978-0-306-45465-3.
^ WG, Kurz; Chatson KB; Constabel F (1981). „Alkaloid Production in Catharanthus roseus Cell Cultures VIII1”. Planta Medica. 42 (5): 22—31. PMID 17401876. doi:10.1055/s-2007-971541.
^ León F, Habib E, Adkins JE, Furr EB, McCurdy CR, Cutler SJ (2009). „Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A”. Natural Product Communications. 4 (7): 907—10. PMID 19731590.
^ Roquebert J, Demichel P (1984). „Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine”. European Journal of Pharmacology. 106 (1): 203—5. PMID 6099269. doi:10.1016/0014-2999(84)90698-8.

Literatura[uredi | uredi izvor]

Wink, Michael; Roberts, M. W. (1998). Alkaloids: biochemistry, ecology, and medicinal applications. New York: Plenum Press. ISBN 978-0-306-45465-3.

[isbn0-306-45465-3-1] а ^б ^в ^г Wink, Michael; Roberts, M. W. (1998). Alkaloids: biochemistry, ecology, and medicinal applications. New York: Plenum Press. ISBN 978-0-306-45465-3.

[pmid17401876-2] WG, Kurz; Chatson KB; Constabel F (1981). „Alkaloid Production in Catharanthus roseus Cell Cultures VIII1”. Planta Medica. 42 (5): 22—31. PMID 17401876. doi:10.1055/s-2007-971541.

[pmid19731590-3] León F, Habib E, Adkins JE, Furr EB, McCurdy CR, Cutler SJ (2009). „Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A”. Natural Product Communications. 4 (7): 907—10. PMID 19731590.

[pmid6099269-4] Roquebert J, Demichel P (1984). „Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine”. European Journal of Pharmacology. 106 (1): 203—5. PMID 6099269. doi:10.1016/0014-2999(84)90698-8.

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