Amitriptilin

Amitriptilin
IUPAC ime
	3-(10,11-dihidro-5H-dibenzo[a,d]ciklohepten-5-iliden)-N,N-dimetilpropan-1-amin
Klinički podaci
Prodajno ime	Triptomer, Elavil
Drugs.com	Monografija
MedlinePlus	a682388
Kategorija trudnoće	US: D (Evidencija rizika) ; ;
Način primene	Oralno
Pravni status
Pravni status	℞ (Prescription only);
Farmakokinetički podaci
Bioraspoloživost	30–60% usled metabolizma prvog prolaza
Vezivanje proteina	> 90%
Metabolizam	Hepatički; CYP2C19, CYP1A2, CYP2D6
Poluvreme eliminacije	10–50 sata, sa prosekom od 15 sata
Izlučivanje	Renalno
Identifikatori
CAS broj	50-48-6 ; 549-18-8 (hidrohlorid)
ATC kod	N06AA09 (WHO)
PubChem	CID 2160
IUPHAR/BPS	200
DrugBank	DB00321
ChemSpider	2075
UNII	1806D8D52K
KEGG	D07448
ChEBI	CHEBI:2666
ChEMBL	CHEMBL629
Hemijski podaci
Formula	C20H23N
Molarna masa	277,403 g/mol
	SMILES c3cc2c(/C(c1c(cccc1)CC2)=C\CCN(C)C)cc3; ;
	InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3 ; Key:KRMDCWKBEZIMAB-UHFFFAOYSA-N ;

Amitriptilin (Triptomer, Elavil, Triptizol, Laroksil, Saroten, Saroteks, Lentizol, Endep) je triciklični antidepresiv (TCA).^[1]^[2] On je najšire korišćeni TCA i jednako je efikasan protiv depresije kao i novija klasa SSRI lekova.^[3] Osim redukovanja simptoma depresije, on olakšava migrene, glavobolje usled napetosti, napade anksioznosti i neke od simptoma šizofrenije. Takođe je poznato da redukuje agresivno i nasilno ponašanje.

Vidi još

Triciklični antidepresivi

Reference

^ Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
^ Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0.
^ Barbui C, Hotopf M (2001). „Amitriptyline v. the rest: still the leading antidepressant after 40 years of randomised controlled trials”. The British Journal of Psychiatry : the Journal of Mental Science. 178 (2): 129—144. PMID 11157426. doi:10.1192/bjp.178.2.129.

Spoljašnje veze

PubChem Substance Summary: Amitriptyline National Center for Biotechnology Information.
TREPILINE-10 TABLETS; TREPILINE-25 TABLETS South African Electronic Package Inserts. 12 May 1978. Revised February 2004.
AMITRIP Amitriptyline hydrochloride 10 mg, 25 mg and 50 mg Capsules Архивирано на сајту Wayback Machine (2. мај 2007) Medsafe NZ Physician Data Sheet. November 2004.
Endep Consumer Medicine Information, Australia. December 2005.
MedlinePlus Drug Information: Amitriptyline. US National Institutes of Health. January 2008.

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u vezi sa temama iz oblasti medicine (zdravlja).

[Goodman_Gilman-1] Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.

[PDR-2] Pdr Staff (2009). PDR: Physicians Desk Reference 2010 (Physicians' Desk Reference (Pdr)). Rozelle, N.S.W: Thomson Reuters. ISBN 1-56363-748-0.

[pmid11157426-3] Barbui C, Hotopf M (2001). „Amitriptyline v. the rest: still the leading antidepressant after 40 years of randomised controlled trials”. The British Journal of Psychiatry : the Journal of Mental Science. 178 (2): 129—144. PMID 11157426. doi:10.1192/bjp.178.2.129.

[1]

[2]

[3]

p r u Modulatori sigma receptora
σ₁	Agonisti: 3-PPP 4-PPBP 5-MeO-DMT Alazocin (SKF-10047) Amantadin ANAVEX2-73 Arketamin BD-737 BD-1052 Kaptodiam Citalopram CGRP Kloperastin Kokain Kutamezin (SA-4503) Ciklazocin Dehidroepiandrosteron (DHEA) (prasteron) Dehidroepiandrosteron sulfat (DHEA-S) (prasteron sulfat) Dekstralorfan Dekstrometorfan (DXM) Dekstrorfan (DXO) Dimemorfan Dimetiltriptamin (DMT) Ditolilgvanidin (DTG) Donepezil Eliprodil Escitalopram Fabomotizol (afobazol) Fluoksetin Fluvoksamin Ifenprodil Igmesin (JO-1784) IPAB Ketamin L-687384 MDMA (midomafetamin) Memantin Metamfetamin Metoksetamin Metilfenidat Nepinalon Neuropeptid Y Noskapin OPC-14523 Opipramol Pentazocin Pentoksiverin (karbetapentan) PRE-084 Pregnenolon Pregnenolon sulfat Pridopidin Racemetorfan (metorfan) Racemorfan (morfanol) UMB-23 UMB-82 Antagonisti: 3-PPP AC-927 BD-1008 BD-1031 BD-1047 BD-1060 BD-1063 BD-1067 BMY-14802 (BMS-181100) CM-156 Dup-734 E-5842 E-52862 (S1RA) Haloperidol LR-132 LR-172 MS-377 NE-100 NPC-16377 Panamesin (EMD-57455) PD-144418 Pentazocin Progesteron Rimkazol (BW-234U) Sertralin SR-31742A Alosterni modulatori: Fenitoin; Pozitivni: Metilfenilpiracetam SOMCL-668 Nepoznati/nerazvrstani: 3-Metoksidekstralorfan 3-MeO-PCP 4C-T-2 4-IBP 4-IPBS 4-MeO-PCP 5-MeO-DALT 5-MeO-DiPT Amitriptilin Azidopamil Hlorpromazin Klemastin Klomipramin Klorgilin D-Deprenil DiPT DPT Ibogain Imipramin KCR-12-83.1 Nemonaprid Noribogain RHL-033 RS-67,333 RTI-55 Šafran Safinamid Selegilin Spipetijan Trifluoperazin W-18 YKP10A
σ₂	Agonisti: 3-PPP Arketamin BD-1047 BD1063 Ditolilgvanidin (DTG) DKR-1005 DKR-1051 Haloperidol Ifenprodil Ketamin MDMA (midomafetamin) Metamfetamin OPC-14523 Opipramol PB-28 Fenciklidin Siramesin (Lu 28-179) UKH-1114 Antagonisti: AC-927 BD-1008 BD-1067 CM-156 CT-1812 LR-172 MIN-101 Panamesin (EMD-57455) SAS-0132 Nepoznati/nerazvrstani: 3-Metoksidekstralorfan 3-MeO-PCE 4-MeO-PCP 5-MeO-DALT 5-MeO-DiPT Klemastin DiPT DPT Ibogain Nemonaprid Nepinalon Noribogain Pentazocin RS-67,333 Safinamid TMA UMB-23 UMB-82 W-18
Neraz- vrstani	Agonisti: Berberin Etilketazocin Forfit Metafit Nalbufin Naluzotan Tapentadol Tenociklidin Antagonisti: AHD1 AZ66 Lamotrigin Nalokson SM-21 UMB-100 UMB-101 UMB-103 UMB-116 YZ-011 YZ-069 YZ-185 Alosterni modulatori: SKF-83959 Nepoznati/nerazvrstani: 18-Metoksikoronaridin BMY-13980 Butaklamol Karamifen Karvotrolin Hlorfenamin (hlorfeniramin) Hlorpromazin Cinarizin Cinuperon Klocapramin Dezocin EMD-59983 Hipericin (kantarion) Flufenazin Gevotrolin (WY-47384) Mepiramin (pirilamin) Molindon Perfenazin Pimozid Proadifen Prometazin Propranolol Hinidin Remoksiprid SL 82.0715 SR-31747A Tiospiron (BMY-13859) Venlafaksin